Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model

Abstract Nonhuman adenoviruses including bovine adenovirus serotype 3 (BAd3) and porcine adenovirus serotype 3 (PAd3) can circumvent pre-existing immunity against human adenovirus serotype 5 (HAd5) and are being developed as alternative vectors for gene delivery. To assess the usefulness of these ve...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2009-03, Vol.386 (1), p.44-54
Hauptverfasser:	Sharma, Anurag, Bangari, Dinesh S, Tandon, Manish, Pandey, Aseem, HogenEsch, Harm, Mittal, Suresh K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - isolation & purification Adenoviridae - physiology Adenovirus Animals Biodistribution Bovine adenovirus DNA, Viral - genetics DNA, Viral - isolation & purification Female Gene Expression Gene therapy Genes, Reporter Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - pharmacokinetics Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Human adenovirus Infectious Disease Injections, Intravenous Mice Models, Animal Nonhuman adenoviral vectors Porcine adenovirus Time Factors Transduction, Genetic
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