Melanoma Proliferation and Chemoresistance Controlled by the DEK Oncogene

Gain of chromosome 6p is a consistent feature of advanced melanomas. However, the identity of putative oncogene(s) associated with this amplification has remained elusive. The chromatin remodeling factor DEK is an attractive candidate as it maps to 6p (within common melanoma-amplified loci). Moreove...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2009-08, Vol.69 (16), p.6405-6413
Hauptverfasser:	KHODADOUST, Michael S, VERHAEGEN, Monique, KAPPES, Ferdinand, RIVEIRO-FALKENBACH, Erica, CIGUDOSA, Juan C, KIM, David S. L, CHINNAIYAN, Arul M, MARKOVITZ, David M, SOENGAS, María S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents bcl-X Protein - metabolism Biological and medical sciences Cell Proliferation Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - genetics Chromosomal Proteins, Non-Histone - antagonists & inhibitors Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomal Proteins, Non-Histone - physiology Chromosomes, Human, Pair 6 Dermatology Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Melanoma - genetics Melanoma - metabolism Melanoma - pathology Myeloid Cell Leukemia Sequence 1 Protein Oncogene Proteins - antagonists & inhibitors Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncogene Proteins - physiology Pharmacology. Drug treatments Poly-ADP-Ribose Binding Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Small Interfering - pharmacology Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the skin and soft tissue. Premalignant lesions
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