Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice
We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre–B-cell proliferation, have variable clinical presentation, are transplan...
Gespeichert in:
| Veröffentlicht in: | Blood 2009-08, Vol.114 (7), p.1374-1382 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1382 |
|---|---|
| container_issue | 7 |
| container_start_page | 1374 |
| container_title | Blood |
| container_volume | 114 |
| creator | Costinean, Stefan Sandhu, Sukhinder K. Pedersen, Irene M. Tili, Esmerina Trotta, Rossana Perrotti, Danilo Ciarlariello, David Neviani, Paolo Harb, Jason Kauffman, Lauren Rachel Shidham, Aaditya Croce, Carlo Maria |
| description | We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre–B-cell proliferation, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion. In this study, we show that in these transgenic mice the B-cell precursors have the highest MiR-155 transgene expression and are at the origin of the leukemias. We determine that Src homology 2 domain–containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein β (C/EBPβ), 2 important regulators of the interleukin-6 signaling pathway, are direct targets of MiR-155 and become gradually more down-regulated in the leukemic than in the preleukemic mice. We hypothesize that miR-155, by down-modulating Ship and C/EBPβ, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma. |
| doi_str_mv | 10.1182/blood-2009-05-220814 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2727407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120374292</els_id><sourcerecordid>S0006497120374292</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-2ee6b5c40f65cb26831d65394db0517b1bfb9d4307fa604b64b969f538465e4e3</originalsourceid><addsrcrecordid>eNp9UUuO1DAQjRCIaQZuwMIbloayY-ezQWpaw0cahATD2vKnkhgldmSHkXo3d-AEXIE1Z5hDcBLSdGsQG1ZVUr336lW9onjK4DljDX9hxhgd5QAtBUk5h4aJe8WGSd5QAA73iw0AVFS0NTsrHuX8BYCJksuHxRlr5YqHalN8_5QsGeIUx9jvCScuTtqHXzffbAzL2vnQEx9i9kscqaTzEPM86EVnJDo4stttt1cEw6CDxUSND-7AmFNc0Ady-4PohGTRqccFHTF7MvmPlEm5ipJXxOI4ZhI7cnH7k74_TZakQ-4xeLuCLT4uHnR6zPjkVM-Lz68vrnZv6eWHN-9220tqRVkvlCNWRloBXSWt4VVTMlfJshXOgGS1YaYzrRMl1J2uQJhKmLZqO1k2opIosDwvXh51569mQmcxrEZGNSc_6bRXUXv17yT4QfXxWvGa1wLqVUAcBWyKOSfs7rgM1CEy9ScydYhMgVTHyFbas9Nena0eu_V66_Mdl7OGtTVnf_3h-oRrj0ll63F9u_MJ7aJc9P9f9Bt0dK7A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Costinean, Stefan ; Sandhu, Sukhinder K. ; Pedersen, Irene M. ; Tili, Esmerina ; Trotta, Rossana ; Perrotti, Danilo ; Ciarlariello, David ; Neviani, Paolo ; Harb, Jason ; Kauffman, Lauren Rachel ; Shidham, Aaditya ; Croce, Carlo Maria</creator><creatorcontrib>Costinean, Stefan ; Sandhu, Sukhinder K. ; Pedersen, Irene M. ; Tili, Esmerina ; Trotta, Rossana ; Perrotti, Danilo ; Ciarlariello, David ; Neviani, Paolo ; Harb, Jason ; Kauffman, Lauren Rachel ; Shidham, Aaditya ; Croce, Carlo Maria</creatorcontrib><description>We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre–B-cell proliferation, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion. In this study, we show that in these transgenic mice the B-cell precursors have the highest MiR-155 transgene expression and are at the origin of the leukemias. We determine that Src homology 2 domain–containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein β (C/EBPβ), 2 important regulators of the interleukin-6 signaling pathway, are direct targets of MiR-155 and become gradually more down-regulated in the leukemic than in the preleukemic mice. We hypothesize that miR-155, by down-modulating Ship and C/EBPβ, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2009-05-220814</identifier><identifier>PMID: 19520806</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Animal tumors. Experimental tumors ; Biological and medical sciences ; Experimental malignant blood diseases ; Hematologic and hematopoietic diseases ; Lymphoid Neoplasia ; Medical sciences ; Tumors</subject><ispartof>Blood, 2009-08, Vol.114 (7), p.1374-1382</ispartof><rights>2009 American Society of Hematology</rights><rights>2009 INIST-CNRS</rights><rights>2009 by The American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-2ee6b5c40f65cb26831d65394db0517b1bfb9d4307fa604b64b969f538465e4e3</citedby><cites>FETCH-LOGICAL-c437t-2ee6b5c40f65cb26831d65394db0517b1bfb9d4307fa604b64b969f538465e4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21819721$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Costinean, Stefan</creatorcontrib><creatorcontrib>Sandhu, Sukhinder K.</creatorcontrib><creatorcontrib>Pedersen, Irene M.</creatorcontrib><creatorcontrib>Tili, Esmerina</creatorcontrib><creatorcontrib>Trotta, Rossana</creatorcontrib><creatorcontrib>Perrotti, Danilo</creatorcontrib><creatorcontrib>Ciarlariello, David</creatorcontrib><creatorcontrib>Neviani, Paolo</creatorcontrib><creatorcontrib>Harb, Jason</creatorcontrib><creatorcontrib>Kauffman, Lauren Rachel</creatorcontrib><creatorcontrib>Shidham, Aaditya</creatorcontrib><creatorcontrib>Croce, Carlo Maria</creatorcontrib><title>Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice</title><title>Blood</title><description>We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre–B-cell proliferation, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion. In this study, we show that in these transgenic mice the B-cell precursors have the highest MiR-155 transgene expression and are at the origin of the leukemias. We determine that Src homology 2 domain–containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein β (C/EBPβ), 2 important regulators of the interleukin-6 signaling pathway, are direct targets of MiR-155 and become gradually more down-regulated in the leukemic than in the preleukemic mice. We hypothesize that miR-155, by down-modulating Ship and C/EBPβ, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma.</description><subject>Animal tumors. Experimental tumors</subject><subject>Biological and medical sciences</subject><subject>Experimental malignant blood diseases</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Lymphoid Neoplasia</subject><subject>Medical sciences</subject><subject>Tumors</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9UUuO1DAQjRCIaQZuwMIbloayY-ezQWpaw0cahATD2vKnkhgldmSHkXo3d-AEXIE1Z5hDcBLSdGsQG1ZVUr336lW9onjK4DljDX9hxhgd5QAtBUk5h4aJe8WGSd5QAA73iw0AVFS0NTsrHuX8BYCJksuHxRlr5YqHalN8_5QsGeIUx9jvCScuTtqHXzffbAzL2vnQEx9i9kscqaTzEPM86EVnJDo4stttt1cEw6CDxUSND-7AmFNc0Ady-4PohGTRqccFHTF7MvmPlEm5ipJXxOI4ZhI7cnH7k74_TZakQ-4xeLuCLT4uHnR6zPjkVM-Lz68vrnZv6eWHN-9220tqRVkvlCNWRloBXSWt4VVTMlfJshXOgGS1YaYzrRMl1J2uQJhKmLZqO1k2opIosDwvXh51569mQmcxrEZGNSc_6bRXUXv17yT4QfXxWvGa1wLqVUAcBWyKOSfs7rgM1CEy9ScydYhMgVTHyFbas9Nena0eu_V66_Mdl7OGtTVnf_3h-oRrj0ll63F9u_MJ7aJc9P9f9Bt0dK7A</recordid><startdate>20090813</startdate><enddate>20090813</enddate><creator>Costinean, Stefan</creator><creator>Sandhu, Sukhinder K.</creator><creator>Pedersen, Irene M.</creator><creator>Tili, Esmerina</creator><creator>Trotta, Rossana</creator><creator>Perrotti, Danilo</creator><creator>Ciarlariello, David</creator><creator>Neviani, Paolo</creator><creator>Harb, Jason</creator><creator>Kauffman, Lauren Rachel</creator><creator>Shidham, Aaditya</creator><creator>Croce, Carlo Maria</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><general>American Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20090813</creationdate><title>Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice</title><author>Costinean, Stefan ; Sandhu, Sukhinder K. ; Pedersen, Irene M. ; Tili, Esmerina ; Trotta, Rossana ; Perrotti, Danilo ; Ciarlariello, David ; Neviani, Paolo ; Harb, Jason ; Kauffman, Lauren Rachel ; Shidham, Aaditya ; Croce, Carlo Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-2ee6b5c40f65cb26831d65394db0517b1bfb9d4307fa604b64b969f538465e4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animal tumors. Experimental tumors</topic><topic>Biological and medical sciences</topic><topic>Experimental malignant blood diseases</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Lymphoid Neoplasia</topic><topic>Medical sciences</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costinean, Stefan</creatorcontrib><creatorcontrib>Sandhu, Sukhinder K.</creatorcontrib><creatorcontrib>Pedersen, Irene M.</creatorcontrib><creatorcontrib>Tili, Esmerina</creatorcontrib><creatorcontrib>Trotta, Rossana</creatorcontrib><creatorcontrib>Perrotti, Danilo</creatorcontrib><creatorcontrib>Ciarlariello, David</creatorcontrib><creatorcontrib>Neviani, Paolo</creatorcontrib><creatorcontrib>Harb, Jason</creatorcontrib><creatorcontrib>Kauffman, Lauren Rachel</creatorcontrib><creatorcontrib>Shidham, Aaditya</creatorcontrib><creatorcontrib>Croce, Carlo Maria</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costinean, Stefan</au><au>Sandhu, Sukhinder K.</au><au>Pedersen, Irene M.</au><au>Tili, Esmerina</au><au>Trotta, Rossana</au><au>Perrotti, Danilo</au><au>Ciarlariello, David</au><au>Neviani, Paolo</au><au>Harb, Jason</au><au>Kauffman, Lauren Rachel</au><au>Shidham, Aaditya</au><au>Croce, Carlo Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice</atitle><jtitle>Blood</jtitle><date>2009-08-13</date><risdate>2009</risdate><volume>114</volume><issue>7</issue><spage>1374</spage><epage>1382</epage><pages>1374-1382</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre–B-cell proliferation, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion. In this study, we show that in these transgenic mice the B-cell precursors have the highest MiR-155 transgene expression and are at the origin of the leukemias. We determine that Src homology 2 domain–containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein β (C/EBPβ), 2 important regulators of the interleukin-6 signaling pathway, are direct targets of MiR-155 and become gradually more down-regulated in the leukemic than in the preleukemic mice. We hypothesize that miR-155, by down-modulating Ship and C/EBPβ, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>19520806</pmid><doi>10.1182/blood-2009-05-220814</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2009-08, Vol.114 (7), p.1374-1382 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2727407 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animal tumors. Experimental tumors Biological and medical sciences Experimental malignant blood diseases Hematologic and hematopoietic diseases Lymphoid Neoplasia Medical sciences Tumors |
| title | Src homology 2 domain–containing inositol-5-phosphatase and CCAAT enhancer-binding protein β are targeted by miR-155 in B cells of Eμ-MiR-155 transgenic mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T00%3A45%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Src%20homology%202%20domain%E2%80%93containing%20inositol-5-phosphatase%20and%20CCAAT%20enhancer-binding%20protein%20%CE%B2%20are%20targeted%20by%20miR-155%20in%20B%20cells%20of%20E%CE%BC-MiR-155%20transgenic%20mice&rft.jtitle=Blood&rft.au=Costinean,%20Stefan&rft.date=2009-08-13&rft.volume=114&rft.issue=7&rft.spage=1374&rft.epage=1382&rft.pages=1374-1382&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2009-05-220814&rft_dat=%3Celsevier_pubme%3ES0006497120374292%3C/elsevier_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/19520806&rft_els_id=S0006497120374292&rfr_iscdi=true |