Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy

Altered microRNA (miRNA) expression profiles have been observed in numerous malignancies, including oral squamous cell carcinoma (OSCC). However, their role in disease is not entirely clear. Several genetic aberrations are characteristic of OSCC, with amplification of chromosomal band 11q13 and loss...

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Veröffentlicht in:	Genes chromosomes & cancer 2009-07, Vol.48 (7), p.569-582
Hauptverfasser:	Henson, Brian J., Bhattacharjee, Samsiddhi, O'Dee, Dawn M., Feingold, Eleanor, Gollin, Susanne M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Blotting, Western Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Cell Line, Tumor Cell Proliferation Cells, Cultured Chromosomes, Human, Pair 11 Down-Regulation Female Gene Expression Regulation, Neoplastic Humans Male MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Oligonucleotide Array Sequence Analysis Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Transfection Young Adult
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