Gene transfer using bovine adeno-associated virus in the guinea pig cochlea

Gene transfer into the cells of the cochlea is useful for both research and therapy. Bovine adeno-associated virus (BAAV) is a new viral vector with potential for long-term gene expression with little or no side effects. In this study, we assessed transgene expression using BAAV with β-actin-GFP as...

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Veröffentlicht in:	Gene therapy 2009-08, Vol.16 (8), p.990-997
Hauptverfasser:	Shibata, S B, Di Pasquale, G, Cortez, S R, Chiorini, J A, Raphael, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - genetics Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedicine Biotechnology Bovine adeno-associated virus Brain stem Care and treatment Cattle Cell Biology Cochlea Cochlea - metabolism Dependovirus - genetics Ears & hearing Epithelium Evoked Potentials, Auditory, Brain Stem - genetics Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene Transfer Techniques Genes, Reporter Genetic aspects Genetic Therapy Genetic Vectors - adverse effects Green Fluorescent Proteins - genetics Guinea Pigs Health. Pharmaceutical industry Hearing loss Hearing Loss - therapy Hogs Human Genetics Industrial applications and implications. Economical aspects Inner ear Inoculation Medical sciences Nanotechnology original-article Pathogenicity Patient outcomes Physiological aspects Reporter gene Transduction Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viruses
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