Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity

LXR agonists alter Th17 cell function and suppress EAE. CD4+ Th17 cells are believed to play an important role in the development of a variety of autoimmune diseases including EAE, an animal model of MS. Previously, we and others demonstrated that LXR agonists suppressed the activation of primary gl...

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Veröffentlicht in:	Journal of leukocyte biology 2009-08, Vol.86 (2), p.401-409
Hauptverfasser:	Xu, Jihong, Wagoner, Gail, Douglas, James C., Drew, Paul D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity - drug effects Autoimmunity - immunology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cells, Cultured cytokines DNA-Binding Proteins - agonists DNA-Binding Proteins - metabolism EAE/MS Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Hydrocarbons, Fluorinated - pharmacology Immune Tolerance - drug effects Immune Tolerance - immunology Immunosuppressive Agents - pharmacology Inflammation, Extracellular Mediators, & Effector Molecules Interleukin-17 - antagonists & inhibitors Interleukin-17 - metabolism Interleukin-22 Interleukin-23 - metabolism Interleukin-23 - pharmacology Interleukins - genetics Liver X Receptors Mice Mice, Inbred C57BL Mice, Transgenic Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Myelin Proteins Myelin-Associated Glycoprotein - immunology Myelin-Oligodendrocyte Glycoprotein Orphan Nuclear Receptors Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Interleukin - drug effects Receptors, Interleukin - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism Sulfonamides - pharmacology T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism
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