Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids

We investigated the role of phospholipase A2 (PLA2) and the effects of PLA2 products (polyunsaturated fatty acids and lysophospholipids) on the cold-sensitive channel transient receptor potential (melastatin)-8 (TRPM8), heterologously expressed in Chinese hamster ovary cells. TRPM8 responses to cold...

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Veröffentlicht in:	The Journal of neuroscience 2007-03, Vol.27 (12), p.3347-3355
Hauptverfasser:	Andersson, David A, Nash, Mark, Bevan, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cold Temperature Cricetinae Cricetulus Dose-Response Relationship, Drug Fatty Acids, Unsaturated - pharmacology Fatty Acids, Unsaturated - physiology Female Lysophospholipids - pharmacology Lysophospholipids - physiology Male Mice Rats Rats, Wistar TRPM Cation Channels - agonists TRPM Cation Channels - metabolism
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