Mothers' anxiety during pregnancy is associated with asthma in their children
Background Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. Objective We tested whether p...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2009-04, Vol.123 (4), p.847-853.e11 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Cookson, Hannah, MB, ChB Granell, Raquel, PhD Joinson, Carol, PhD Ben-Shlomo, Yoav, PhD Henderson, A. John, MD |
| description | Background Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. Objective We tested whether prenatal and postnatal anxiety and/or depression in pregnant women predicted the risk of their offspring developing asthma in childhood. Methods The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7½ years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7½ years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI). Results Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7½ years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response ( P value for trend |
| doi_str_mv | 10.1016/j.jaci.2009.01.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2726292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091674909001584</els_id><sourcerecordid>3239304071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c566t-eae72474dc50046982fac77a9b051ed1e3369523306e9990d1fdc6731d829ad83</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhiMEokvhD3BAkRBwyuKv2LGEKqGKL6kVB-BsufZkMyHrbO2ksP8eR7tqoQdO1miedzwz7xTFc0rWlFD5tl_31uGaEaLXhK6JYA-KFSVaVbJh9cNilRO0kkrok-JJSj3JMW_04-KEai4azcSquLwcpw5ielPa8Bth2pd-jhg25S7CJtjg9iWm0qY0OrQT-PIXTl2Op25rSwxlFmMsXYeDjxCeFo9aOyR4dnxPix8fP3w__1xdfP305fz9ReVqKacKLCgmlPCuJkRI3bDWOqWsviI1BU-Bc6lrxjmRoLUmnrbeScWpb5i2vuGnxdmh7m6-2oJ3EKZoB7OLuLVxb0aL5t9MwM5sxhvDFJNMs1zg9bFAHK9nSJPZYnIwDDbAOCcjFWV5iSKDL--B_TjHkIcztCaioUxpmil2oFwcU4rQ3rZCiVm8Mr1ZvDKLV4ZQk73Kohd_D3EnOZqTgVdHwCZnhzZmOzDdcoxyVctaZu7dgYO88huEaJJDCA48RnCT8SP-v4-ze3I3YMD840_YQ7qb1yRmiPm2XNVyVEQTQutG8D-nBMcl</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504812791</pqid></control><display><type>article</type><title>Mothers' anxiety during pregnancy is associated with asthma in their children</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cookson, Hannah, MB, ChB ; Granell, Raquel, PhD ; Joinson, Carol, PhD ; Ben-Shlomo, Yoav, PhD ; Henderson, A. John, MD</creator><creatorcontrib>Cookson, Hannah, MB, ChB ; Granell, Raquel, PhD ; Joinson, Carol, PhD ; Ben-Shlomo, Yoav, PhD ; Henderson, A. John, MD</creatorcontrib><description>Background Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. Objective We tested whether prenatal and postnatal anxiety and/or depression in pregnant women predicted the risk of their offspring developing asthma in childhood. Methods The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7½ years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7½ years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI). Results Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7½ years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response ( P value for trend <0.001). Conclusions Maternal anxiety symptoms as an indicator of stress during fetal life may program the development of asthma during childhood.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2009.01.042</identifier><identifier>PMID: 19348924</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Allergy and Immunology ; Anxiety ; Anxiety - complications ; Asthma ; Asthma - etiology ; Asthma and Lower Airway Disease ; Biological and medical sciences ; Child ; Children & youth ; Chronic obstructive pulmonary disease, asthma ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunopathology ; Infant, Newborn ; Male ; Medical sciences ; Pneumology ; Pregnancy ; Pregnancy Complications ; prenatal programming ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Womens health</subject><ispartof>Journal of allergy and clinical immunology, 2009-04, Vol.123 (4), p.847-853.e11</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2009 American Academy of Allergy, Asthma & Immunology</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Limited Apr 2009</rights><rights>2009 Mosby, Inc. 2009 American Academy of Allergy, Asthma & Immunology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-eae72474dc50046982fac77a9b051ed1e3369523306e9990d1fdc6731d829ad83</citedby><cites>FETCH-LOGICAL-c566t-eae72474dc50046982fac77a9b051ed1e3369523306e9990d1fdc6731d829ad83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2009.01.042$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21375656$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19348924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cookson, Hannah, MB, ChB</creatorcontrib><creatorcontrib>Granell, Raquel, PhD</creatorcontrib><creatorcontrib>Joinson, Carol, PhD</creatorcontrib><creatorcontrib>Ben-Shlomo, Yoav, PhD</creatorcontrib><creatorcontrib>Henderson, A. John, MD</creatorcontrib><title>Mothers' anxiety during pregnancy is associated with asthma in their children</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. Objective We tested whether prenatal and postnatal anxiety and/or depression in pregnant women predicted the risk of their offspring developing asthma in childhood. Methods The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7½ years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7½ years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI). Results Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7½ years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response ( P value for trend <0.001). Conclusions Maternal anxiety symptoms as an indicator of stress during fetal life may program the development of asthma during childhood.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Anxiety</subject><subject>Anxiety - complications</subject><subject>Asthma</subject><subject>Asthma - etiology</subject><subject>Asthma and Lower Airway Disease</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Children & youth</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>prenatal programming</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Womens health</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1v1DAQhiMEokvhD3BAkRBwyuKv2LGEKqGKL6kVB-BsufZkMyHrbO2ksP8eR7tqoQdO1miedzwz7xTFc0rWlFD5tl_31uGaEaLXhK6JYA-KFSVaVbJh9cNilRO0kkrok-JJSj3JMW_04-KEai4azcSquLwcpw5ielPa8Bth2pd-jhg25S7CJtjg9iWm0qY0OrQT-PIXTl2Op25rSwxlFmMsXYeDjxCeFo9aOyR4dnxPix8fP3w__1xdfP305fz9ReVqKacKLCgmlPCuJkRI3bDWOqWsviI1BU-Bc6lrxjmRoLUmnrbeScWpb5i2vuGnxdmh7m6-2oJ3EKZoB7OLuLVxb0aL5t9MwM5sxhvDFJNMs1zg9bFAHK9nSJPZYnIwDDbAOCcjFWV5iSKDL--B_TjHkIcztCaioUxpmil2oFwcU4rQ3rZCiVm8Mr1ZvDKLV4ZQk73Kohd_D3EnOZqTgVdHwCZnhzZmOzDdcoxyVctaZu7dgYO88huEaJJDCA48RnCT8SP-v4-ze3I3YMD840_YQ7qb1yRmiPm2XNVyVEQTQutG8D-nBMcl</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Cookson, Hannah, MB, ChB</creator><creator>Granell, Raquel, PhD</creator><creator>Joinson, Carol, PhD</creator><creator>Ben-Shlomo, Yoav, PhD</creator><creator>Henderson, A. John, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><general>Mosby</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090401</creationdate><title>Mothers' anxiety during pregnancy is associated with asthma in their children</title><author>Cookson, Hannah, MB, ChB ; Granell, Raquel, PhD ; Joinson, Carol, PhD ; Ben-Shlomo, Yoav, PhD ; Henderson, A. John, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-eae72474dc50046982fac77a9b051ed1e3369523306e9990d1fdc6731d829ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Anxiety</topic><topic>Anxiety - complications</topic><topic>Asthma</topic><topic>Asthma - etiology</topic><topic>Asthma and Lower Airway Disease</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Children & youth</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>prenatal programming</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cookson, Hannah, MB, ChB</creatorcontrib><creatorcontrib>Granell, Raquel, PhD</creatorcontrib><creatorcontrib>Joinson, Carol, PhD</creatorcontrib><creatorcontrib>Ben-Shlomo, Yoav, PhD</creatorcontrib><creatorcontrib>Henderson, A. John, MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cookson, Hannah, MB, ChB</au><au>Granell, Raquel, PhD</au><au>Joinson, Carol, PhD</au><au>Ben-Shlomo, Yoav, PhD</au><au>Henderson, A. John, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mothers' anxiety during pregnancy is associated with asthma in their children</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>123</volume><issue>4</issue><spage>847</spage><epage>853.e11</epage><pages>847-853.e11</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background Maternal stress in early life has been associated with the development of asthma in children, although it is unclear whether there are any critical periods of exposure. The association of asthma with prenatal exposure to maternal stress has not been reported. Objective We tested whether prenatal and postnatal anxiety and/or depression in pregnant women predicted the risk of their offspring developing asthma in childhood. Methods The Avon Longitudinal Study of Parents and Children is a population-based birth cohort recruited during pregnancy. Data were available on maternal anxiety scores and asthma at age 7½ years in 5810 children. Anxiety was assessed at 18 and 32 weeks of gestation by using the validated Crown-Crisp Experiential Index. Asthma was defined at age 7½ years as doctor-diagnosed asthma with current symptoms or treatment in the previous 12 months. Multivariable logistic regression was used to determine the association of prenatal anxiety with asthma (odds ratio; 95% CI). Results Independent of postnatal anxiety and adjusted for a number of likely confounders, there was a higher likelihood of asthma at age 7½ years (odds ratio, 1.64; 95% CI, 1.25-2.17) in children of mothers in the highest compared with lowest quartile of anxiety scores at 32 weeks of gestation, with evidence for a dose-response ( P value for trend <0.001). Conclusions Maternal anxiety symptoms as an indicator of stress during fetal life may program the development of asthma during childhood.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19348924</pmid><doi>10.1016/j.jaci.2009.01.042</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Allergy and Immunology Anxiety Anxiety - complications Asthma Asthma - etiology Asthma and Lower Airway Disease Biological and medical sciences Child Children & youth Chronic obstructive pulmonary disease, asthma Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Infant, Newborn Male Medical sciences Pneumology Pregnancy Pregnancy Complications prenatal programming Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Womens health |
| title | Mothers' anxiety during pregnancy is associated with asthma in their children |
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