Effect of lymphadenectomy extent on advanced gastric cancer located in the cardia and fundus
AIM： To analyze the prognostic impact of lymphade-nectomy extent in advanced gastric cancer located in the cardia and fundus. METHODS： Two hundred and thirty-six patients with advanced gastric cancer located in the cardia and fundus who underwent D2 curative resection were analyzed retrospectively....
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2008-07, Vol.14 (26), p.4216-4221 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Huang, Chang-Ming Lin, Bi-Juan Lu, Hui-Shan Zhang, Xiang-Fu Li, Ping Xie, Jian-Wei |
| description | AIM： To analyze the prognostic impact of lymphade-nectomy extent in advanced gastric cancer located in the cardia and fundus. METHODS： Two hundred and thirty-six patients with advanced gastric cancer located in the cardia and fundus who underwent D2 curative resection were analyzed retrospectively. Relationships between the numbers of lymph nodes （LNs） dissected and survival was analyzed among different clinical stage subgroups. RESULTS： The 5-year overall survival rate of the entire cohort was 37.5%. Multivariate prognostic variables were total LNs dissected （P 〈 0.0001; or number of negative LNs examined, P 〈 0.0001）, number of positive LNs （P 〈 0.0001）, T category （P 〈 0.0001） and tumor size （P = 0.015）. The greatest survival differences were observed at cutoff values of 20 LNs resected for stage Ⅱ（p = 0.0136）, 25 for stage Ⅲ（P 〈 0.0001）, 30 for stage Ⅳ（P = 0.0002）, and 15 for all patients （P = 0.0024）. Based on the statistically assumed linearity as best fit, linear regression showed a significant survival enhancement based on increasing negative LNs for patients of stages Ⅲ （P = 0.013） and Ⅳ（P = 0.035）. CONCLUSION： To improve the long-term survival of patients with advanced gastric cancer located in the cardia and fundus, removing at least 20 LNs for stage Ⅱ,25 LNs for stage Ⅲ, and 30 LNs for stage N patients during D2 radical dissection is recommended. |
| doi_str_mv | 10.3748/wjg.14.4216 |
| format | Article |
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METHODS： Two hundred and thirty-six patients with advanced gastric cancer located in the cardia and fundus who underwent D2 curative resection were analyzed retrospectively. Relationships between the numbers of lymph nodes （LNs） dissected and survival was analyzed among different clinical stage subgroups. RESULTS： The 5-year overall survival rate of the entire cohort was 37.5%. Multivariate prognostic variables were total LNs dissected （P 〈 0.0001; or number of negative LNs examined, P 〈 0.0001）, number of positive LNs （P 〈 0.0001）, T category （P 〈 0.0001） and tumor size （P = 0.015）. The greatest survival differences were observed at cutoff values of 20 LNs resected for stage Ⅱ（p = 0.0136）, 25 for stage Ⅲ（P 〈 0.0001）, 30 for stage Ⅳ（P = 0.0002）, and 15 for all patients （P = 0.0024）. Based on the statistically assumed linearity as best fit, linear regression showed a significant survival enhancement based on increasing negative LNs for patients of stages Ⅲ （P = 0.013） and Ⅳ（P = 0.035）. CONCLUSION： To improve the long-term survival of patients with advanced gastric cancer located in the cardia and fundus, removing at least 20 LNs for stage Ⅱ,25 LNs for stage Ⅲ, and 30 LNs for stage N patients during D2 radical dissection is recommended.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.14.4216</identifier><identifier>PMID: 18636669</identifier><language>eng</language><publisher>United States: Department of Oncology,Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China</publisher><subject>Adult ; Aged ; Cardia ; Female ; Gastric Fundus ; Humans ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasm Staging ; Rapid Communication ; Retrospective Studies ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; 手术治疗</subject><ispartof>World journal of gastroenterology : WJG, 2008-07, Vol.14 (26), p.4216-4221</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2008 The WJG Press and Baishideng. All rights reserved. 2008</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-7c1d6ed377e8c62bfeea829ac76d79e74c8f89c3ced0b39875725643e1612e563</citedby><cites>FETCH-LOGICAL-c435t-7c1d6ed377e8c62bfeea829ac76d79e74c8f89c3ced0b39875725643e1612e563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725385/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725385/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18636669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chang-Ming</creatorcontrib><creatorcontrib>Lin, Bi-Juan</creatorcontrib><creatorcontrib>Lu, Hui-Shan</creatorcontrib><creatorcontrib>Zhang, Xiang-Fu</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Xie, Jian-Wei</creatorcontrib><title>Effect of lymphadenectomy extent on advanced gastric cancer located in the cardia and fundus</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To analyze the prognostic impact of lymphade-nectomy extent in advanced gastric cancer located in the cardia and fundus. METHODS： Two hundred and thirty-six patients with advanced gastric cancer located in the cardia and fundus who underwent D2 curative resection were analyzed retrospectively. Relationships between the numbers of lymph nodes （LNs） dissected and survival was analyzed among different clinical stage subgroups. RESULTS： The 5-year overall survival rate of the entire cohort was 37.5%. Multivariate prognostic variables were total LNs dissected （P 〈 0.0001; or number of negative LNs examined, P 〈 0.0001）, number of positive LNs （P 〈 0.0001）, T category （P 〈 0.0001） and tumor size （P = 0.015）. The greatest survival differences were observed at cutoff values of 20 LNs resected for stage Ⅱ（p = 0.0136）, 25 for stage Ⅲ（P 〈 0.0001）, 30 for stage Ⅳ（P = 0.0002）, and 15 for all patients （P = 0.0024）. Based on the statistically assumed linearity as best fit, linear regression showed a significant survival enhancement based on increasing negative LNs for patients of stages Ⅲ （P = 0.013） and Ⅳ（P = 0.035）. CONCLUSION： To improve the long-term survival of patients with advanced gastric cancer located in the cardia and fundus, removing at least 20 LNs for stage Ⅱ,25 LNs for stage Ⅲ, and 30 LNs for stage N patients during D2 radical dissection is recommended.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardia</subject><subject>Female</subject><subject>Gastric Fundus</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Rapid Communication</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>手术治疗</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkcuLFDEQxoMo7uzoybsEkb1Ij3l0J-nLgizrAxa86E0ImaTS02N3Mpt07zr_vWlm8HEKVfXx5Vf1IfSKkg2XtXr_uO82tN7UjIonaMUYbSumavIUrSghsmo5kxfoMuc9IYzzhj1HF1QJLoRoV-jHrfdgJxw9Ho7jYWcchFLH8Yjh1wShTAI27sEECw53Jk-pt9guZcJDtGYq7T7gaQelm1xvsAkO-zm4Ob9Az7wZMrw8v2v0_ePtt5vP1d3XT19uPtxVtubNVElLnQDHpQRlBdt6AKNYa6wUTrYga6u8ai0vBGTLWyUbyRpRc6CCMmgEX6Prk-9h3o7gbMFOZtCH1I8mHXU0vf5_Evqd7uKDZsWIq6YYvD0ZPJrgTej0Ps4pFGRdjssIUUwQqors6vxPivcz5EmPfbYwDCZAnLMWy63bcuU1encS2hRzTuD_sFCil9AWX01rvYRW1K__xf-rPadUBG_OdrsYuvu-AG6N_en7AcoKLRUNIfw33PKfWQ</recordid><startdate>20080714</startdate><enddate>20080714</enddate><creator>Huang, Chang-Ming</creator><creator>Lin, Bi-Juan</creator><creator>Lu, Hui-Shan</creator><creator>Zhang, Xiang-Fu</creator><creator>Li, Ping</creator><creator>Xie, Jian-Wei</creator><general>Department of Oncology,Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China</general><general>The WJG Press and Baishideng</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20080714</creationdate><title>Effect of lymphadenectomy extent on advanced gastric cancer located in the cardia and fundus</title><author>Huang, Chang-Ming ; Lin, Bi-Juan ; Lu, Hui-Shan ; Zhang, Xiang-Fu ; Li, Ping ; Xie, Jian-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-7c1d6ed377e8c62bfeea829ac76d79e74c8f89c3ced0b39875725643e1612e563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardia</topic><topic>Female</topic><topic>Gastric Fundus</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Rapid Communication</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>手术治疗</topic><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chang-Ming</creatorcontrib><creatorcontrib>Lin, Bi-Juan</creatorcontrib><creatorcontrib>Lu, Hui-Shan</creatorcontrib><creatorcontrib>Zhang, Xiang-Fu</creatorcontrib><creatorcontrib>Li, Ping</creatorcontrib><creatorcontrib>Xie, Jian-Wei</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chang-Ming</au><au>Lin, Bi-Juan</au><au>Lu, Hui-Shan</au><au>Zhang, Xiang-Fu</au><au>Li, Ping</au><au>Xie, Jian-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of lymphadenectomy extent on advanced gastric cancer located in the cardia and fundus</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2008-07-14</date><risdate>2008</risdate><volume>14</volume><issue>26</issue><spage>4216</spage><epage>4221</epage><pages>4216-4221</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To analyze the prognostic impact of lymphade-nectomy extent in advanced gastric cancer located in the cardia and fundus. METHODS： Two hundred and thirty-six patients with advanced gastric cancer located in the cardia and fundus who underwent D2 curative resection were analyzed retrospectively. Relationships between the numbers of lymph nodes （LNs） dissected and survival was analyzed among different clinical stage subgroups. RESULTS： The 5-year overall survival rate of the entire cohort was 37.5%. Multivariate prognostic variables were total LNs dissected （P 〈 0.0001; or number of negative LNs examined, P 〈 0.0001）, number of positive LNs （P 〈 0.0001）, T category （P 〈 0.0001） and tumor size （P = 0.015）. The greatest survival differences were observed at cutoff values of 20 LNs resected for stage Ⅱ（p = 0.0136）, 25 for stage Ⅲ（P 〈 0.0001）, 30 for stage Ⅳ（P = 0.0002）, and 15 for all patients （P = 0.0024）. Based on the statistically assumed linearity as best fit, linear regression showed a significant survival enhancement based on increasing negative LNs for patients of stages Ⅲ （P = 0.013） and Ⅳ（P = 0.035）. CONCLUSION： To improve the long-term survival of patients with advanced gastric cancer located in the cardia and fundus, removing at least 20 LNs for stage Ⅱ,25 LNs for stage Ⅲ, and 30 LNs for stage N patients during D2 radical dissection is recommended.</abstract><cop>United States</cop><pub>Department of Oncology,Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China</pub><pmid>18636669</pmid><doi>10.3748/wjg.14.4216</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2008-07, Vol.14 (26), p.4216-4221 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Cardia Female Gastric Fundus Humans Lymph Node Excision Male Middle Aged Neoplasm Staging Rapid Communication Retrospective Studies Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach Neoplasms - surgery 手术治疗 |
| title | Effect of lymphadenectomy extent on advanced gastric cancer located in the cardia and fundus |
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