Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

Descending input from the rostral ventromedial medulla (RVM) provides positive and negative modulation of spinal nociceptive transmission and has been proposed to be critical for maintaining neuropathic pain. This study tests the hypothesis that neuropathic pain requires the activity of a subset of...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2009-03, Vol.132 (3), p.778-787
Hauptverfasser:	Zhang, Wenjun, Gardell, Shannon, Zhang, Dongqin, Xie, Jennifer Y., Agnes, Richard S., Badghisi, Hamid, Hruby, Victor J., Rance, Naomi, Ossipov, Michael H., Vanderah, Todd W., Porreca, Frank, Lai, Josephine
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - antagonists & inhibitors Analgesics, Opioid - pharmacology Animals Biological and medical sciences Brain Stem - drug effects Brain Stem - metabolism Brain Stem - pathology cholecystokinin receptor Fundamental and applied biological sciences. Psychology Immunotoxins - pharmacology In Situ Hybridization - methods Isolated neuron and nerve. Neuroglia Male Medical sciences Medulla Oblongata - drug effects Medulla Oblongata - metabolism Medulla Oblongata - pathology Microinjections - methods Morphine - antagonists & inhibitors Morphine - pharmacology Neuralgia - metabolism Neuralgia - pathology Neurology Neurons - drug effects Neurons - metabolism Neurons - physiology neuropathy nociception Opioid Peptides - pharmacology opioid receptor Original Rats Rats, Sprague-Dawley Receptor, Cholecystokinin B - genetics Receptor, Cholecystokinin B - metabolism Receptors, Opioid, mu - metabolism Ribosome Inactivating Proteins, Type 1 - pharmacology RNA, Messenger - genetics rostral ventromedial medulla Sincalide - pharmacology Synaptic Transmission - physiology Vertebrates: nervous system and sense organs
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