Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae

Methylation of lysine 79 on histone H3 by Dot1 is required for maintenance of heterochromatin structure in yeast and humans. However, this histone modification occurs predominantly in euchromatin. Thus, Dot1 affects silencing by indirect mechanisms and does not act by the recruitment model commonly...

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Veröffentlicht in:	BMC molecular biology 2009-07, Vol.10 (1), p.76-76, Article 76
Hauptverfasser:	Verzijlbergen, Kitty F, Faber, Alex W, Stulemeijer, Iris Je, van Leeuwen, Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Brewer's yeast Chromatin Gene Deletion Gene Expression Regulation, Fungal Gene Silencing Genetic aspects Heterochromatin Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Histone Deacetylases - genetics Histone Deacetylases - metabolism Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones Histones - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Physiological aspects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism Sirtuin 2 Sirtuins - genetics Sirtuins - metabolism
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