No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned

The steroid 5-alpha reductase type II gene (SRD5A2) encodes the enzyme which converts testosterone (T) to the more active androgen dihydrotestosterone. A non-synonymous single-nucleotide polymorphism, A49T (rs9282858), in SRD5A2 has been implicated in prostate cancer risk; however, results have been...

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Veröffentlicht in:	Human molecular genetics 2008-08, Vol.17 (16), p.2456-2461
Hauptverfasser:	Pearce, C. Leigh, Van Den Berg, David J., Makridakis, Nick, Reichardt, Juergen K.V., Ross, Ronald K., Pike, Malcolm C., Kolonel, Laurence N., Henderson, Brian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism Aged Biological and medical sciences California Case-Control Studies Cohort Studies Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease - ethnology Genetics of eukaryotes. Biological and molecular evolution Genotype Hawaii Humans Male Medical sciences Middle Aged Molecular and cellular biology Mutation, Missense Nephrology. Urinary tract diseases Odds Ratio Point Mutation Polymorphism, Genetic Prostatic Neoplasms - ethnology Prostatic Neoplasms - genetics Risk Assessment Tumors of the urinary system Urinary tract. Prostate gland
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