Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

Histone deacetylase (HDAC) inhibitors have the potential to derepress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. In the present study, we screened several garlic-derived small organosulfur compounds for their ability to inhibit HDAC activity in vitro....

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Veröffentlicht in:	Carcinogenesis (New York) 2008-09, Vol.29 (9), p.1816-1824
Hauptverfasser:	Nian, Hui, Delage, Barbara, Pinto, John T., Dashwood, Roderick H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Allium sativum Allyl Compounds - pharmacology Binding, Competitive Biological and medical sciences Cancer Prevention Carcinogenesis, carcinogens and anticarcinogens Cell Cycle - drug effects Cell Proliferation - drug effects Chromatin Immunoprecipitation Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Flow Cytometry Garlic Gene Expression Regulation, Neoplastic - drug effects Histone Deacetylase 1 Histone Deacetylase Inhibitors Histone Deacetylases - metabolism Histones - metabolism HT29 Cells Humans Immunoblotting Medical sciences Models, Molecular Promoter Regions, Genetic - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sp1 Transcription Factor - metabolism Sp3 Transcription Factor - metabolism Transcription, Genetic - drug effects Transcriptional Activation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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