Equivalence of Protein Inventories Obtained from Formalin-fixed Paraffin-embedded and Frozen Tissue in Multidimensional Liquid Chromatography-Tandem Mass Spectrometry Shotgun Proteomic Analysis

Formalin-fixed paraffin-embedded (FFPE) tissue specimens comprise a potentially valuable resource for retrospective biomarker discovery studies, and recent work indicates the feasibility of using shotgun proteomics to characterize FFPE tissue proteins. A critical question in the field is whether pro...

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Veröffentlicht in:	Molecular & cellular proteomics 2009-08, Vol.8 (8), p.1988-1998
Hauptverfasser:	Sprung, Robert W., Brock, Jonathan W.C., Tanksley, Jarred P., Li, Ming, Washington, Mary Kay, Slebos, Robbert J.C., Liebler, Daniel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - metabolism Adenoma - pathology Chromatography, Liquid - methods Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Fixatives - chemistry Formaldehyde - chemistry Frozen Sections - methods Humans Paraffin Embedding - methods Proteins - analysis Proteins - metabolism Proteomics - methods Reproducibility of Results Tandem Mass Spectrometry - methods Time Factors Tissue Fixation - methods Tissue Preservation - methods
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