Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer
Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a kno...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (31), p.12909-12914 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 12914 |
|---|---|
| container_issue | 31 |
| container_start_page | 12909 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 106 |
| creator | Graveel, Carrie R DeGroot, Jack D Su, Yanli Koeman, Julie Dykema, Karl Leung, Samuel Snider, Jacqueline Davies, Sherri R Swiatek, Pamela J Cottingham, Sandra Watson, Mark A Ellis, Matthew J Sigler, Robert E Furge, Kyle A Vande Woude, George F |
| description | Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Metmut) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ERBB2 expression, and expression of cytokeratin 5. With gene expression and tissue microarray analysis, we show that high MET expression in human breast cancers significantly correlated with estrogen receptor negative/ERBB2 negative tumors and with basal breast cancers. Few treatment options exist for breast cancers of the basal or trastuzumab-resistant ERBB2 subtypes. We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target. |
| doi_str_mv | 10.1073/pnas.0810403106 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2722304</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40484624</jstor_id><sourcerecordid>40484624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-d3e0db5453037feaf8766ce4c149accd9ac2eb7a74fa3b2cd3b728f91a2a2e3b3</originalsourceid><addsrcrecordid>eNqFkb2P1DAQxS0E4paFmgqwKJAo9m78ESdpkNCJL-kQBVxtTZzJrVdJvNjJAf89jnZ1CzQ042J-72meH2NPBZwLKNXFfsR0DpUADUqAucdWAmqxMbqG-2wFIMtNpaU-Y49S2gFAXVTwkJ2JujBlpcSK2c80cT-2s6PEW39LMREfcBgw_uIOo_NjGDBlhA_eEcex5T5xTCk4jxO1_Ieftnw7DzjyBhP2vImEacri0VF8zB502Cd6cnzX7Pr9u2-XHzdXXz58unx7tXFFoadNqwjaptCFAlV2hF1VGuNIO6FrdK7NQ1JTYqk7VI10rWpKWXW1QImSVKPW7M3Bdz83A7WOxilib_fRL0lsQG__3ox-a2_CrZWllAp0Nnh1NIjh-0xpsoNPjvoeRwpzshIqKGRRZPDlP-AuzHHM4TIjtDCQDdfs4gC5GFKK1N1dIsAuzdmlOXtqLiue_xngxB-rygA_AovyZGesElbIGuqMvP4PYru57yf6OWX22YHdpSnEO1iDrrSRy3-8OOw7DBZvok_2-msOqEAYo7Ws1G-AVcHt</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201416022</pqid></control><display><type>article</type><title>Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Graveel, Carrie R ; DeGroot, Jack D ; Su, Yanli ; Koeman, Julie ; Dykema, Karl ; Leung, Samuel ; Snider, Jacqueline ; Davies, Sherri R ; Swiatek, Pamela J ; Cottingham, Sandra ; Watson, Mark A ; Ellis, Matthew J ; Sigler, Robert E ; Furge, Kyle A ; Vande Woude, George F</creator><creatorcontrib>Graveel, Carrie R ; DeGroot, Jack D ; Su, Yanli ; Koeman, Julie ; Dykema, Karl ; Leung, Samuel ; Snider, Jacqueline ; Davies, Sherri R ; Swiatek, Pamela J ; Cottingham, Sandra ; Watson, Mark A ; Ellis, Matthew J ; Sigler, Robert E ; Furge, Kyle A ; Vande Woude, George F</creatorcontrib><description>Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Metmut) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ERBB2 expression, and expression of cytokeratin 5. With gene expression and tissue microarray analysis, we show that high MET expression in human breast cancers significantly correlated with estrogen receptor negative/ERBB2 negative tumors and with basal breast cancers. Few treatment options exist for breast cancers of the basal or trastuzumab-resistant ERBB2 subtypes. We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0810403106</identifier><identifier>PMID: 19567831</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adenocarcinoma ; Adenocarcinoma - etiology ; Adenocarcinoma - genetics ; Animals ; Basal cell carcinoma ; Biological Sciences ; Breast cancer ; Breast Neoplasms - etiology ; Breast Neoplasms - genetics ; Breasts ; Cancer ; Correlation analysis ; Female ; Gene Amplification ; Gene expression ; Humans ; Immunohistochemistry ; Laboratory staining techniques ; Mammary Neoplasms, Experimental - etiology ; Mammary Neoplasms, Experimental - genetics ; Mice ; Mice, Inbred C57BL ; Oncogenes ; Proto-Oncogene Proteins c-met - genetics ; Proto-Oncogene Proteins c-met - physiology ; Receptor, ErbB-2 - analysis ; Receptors, Progesterone - analysis ; Rodents ; Signal Transduction ; Signatures ; Tumors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (31), p.12909-12914</ispartof><rights>Copyright National Academy of Sciences Aug 4, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-d3e0db5453037feaf8766ce4c149accd9ac2eb7a74fa3b2cd3b728f91a2a2e3b3</citedby><cites>FETCH-LOGICAL-c554t-d3e0db5453037feaf8766ce4c149accd9ac2eb7a74fa3b2cd3b728f91a2a2e3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/106/31.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40484624$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40484624$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19567831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Graveel, Carrie R</creatorcontrib><creatorcontrib>DeGroot, Jack D</creatorcontrib><creatorcontrib>Su, Yanli</creatorcontrib><creatorcontrib>Koeman, Julie</creatorcontrib><creatorcontrib>Dykema, Karl</creatorcontrib><creatorcontrib>Leung, Samuel</creatorcontrib><creatorcontrib>Snider, Jacqueline</creatorcontrib><creatorcontrib>Davies, Sherri R</creatorcontrib><creatorcontrib>Swiatek, Pamela J</creatorcontrib><creatorcontrib>Cottingham, Sandra</creatorcontrib><creatorcontrib>Watson, Mark A</creatorcontrib><creatorcontrib>Ellis, Matthew J</creatorcontrib><creatorcontrib>Sigler, Robert E</creatorcontrib><creatorcontrib>Furge, Kyle A</creatorcontrib><creatorcontrib>Vande Woude, George F</creatorcontrib><title>Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Metmut) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ERBB2 expression, and expression of cytokeratin 5. With gene expression and tissue microarray analysis, we show that high MET expression in human breast cancers significantly correlated with estrogen receptor negative/ERBB2 negative tumors and with basal breast cancers. Few treatment options exist for breast cancers of the basal or trastuzumab-resistant ERBB2 subtypes. We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - etiology</subject><subject>Adenocarcinoma - genetics</subject><subject>Animals</subject><subject>Basal cell carcinoma</subject><subject>Biological Sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Breasts</subject><subject>Cancer</subject><subject>Correlation analysis</subject><subject>Female</subject><subject>Gene Amplification</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Laboratory staining techniques</subject><subject>Mammary Neoplasms, Experimental - etiology</subject><subject>Mammary Neoplasms, Experimental - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Oncogenes</subject><subject>Proto-Oncogene Proteins c-met - genetics</subject><subject>Proto-Oncogene Proteins c-met - physiology</subject><subject>Receptor, ErbB-2 - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Signatures</subject><subject>Tumors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb2P1DAQxS0E4paFmgqwKJAo9m78ESdpkNCJL-kQBVxtTZzJrVdJvNjJAf89jnZ1CzQ042J-72meH2NPBZwLKNXFfsR0DpUADUqAucdWAmqxMbqG-2wFIMtNpaU-Y49S2gFAXVTwkJ2JujBlpcSK2c80cT-2s6PEW39LMREfcBgw_uIOo_NjGDBlhA_eEcex5T5xTCk4jxO1_Ieftnw7DzjyBhP2vImEacri0VF8zB502Cd6cnzX7Pr9u2-XHzdXXz58unx7tXFFoadNqwjaptCFAlV2hF1VGuNIO6FrdK7NQ1JTYqk7VI10rWpKWXW1QImSVKPW7M3Bdz83A7WOxilib_fRL0lsQG__3ox-a2_CrZWllAp0Nnh1NIjh-0xpsoNPjvoeRwpzshIqKGRRZPDlP-AuzHHM4TIjtDCQDdfs4gC5GFKK1N1dIsAuzdmlOXtqLiue_xngxB-rygA_AovyZGesElbIGuqMvP4PYru57yf6OWX22YHdpSnEO1iDrrSRy3-8OOw7DBZvok_2-msOqEAYo7Ws1G-AVcHt</recordid><startdate>20090804</startdate><enddate>20090804</enddate><creator>Graveel, Carrie R</creator><creator>DeGroot, Jack D</creator><creator>Su, Yanli</creator><creator>Koeman, Julie</creator><creator>Dykema, Karl</creator><creator>Leung, Samuel</creator><creator>Snider, Jacqueline</creator><creator>Davies, Sherri R</creator><creator>Swiatek, Pamela J</creator><creator>Cottingham, Sandra</creator><creator>Watson, Mark A</creator><creator>Ellis, Matthew J</creator><creator>Sigler, Robert E</creator><creator>Furge, Kyle A</creator><creator>Vande Woude, George F</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20090804</creationdate><title>Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer</title><author>Graveel, Carrie R ; DeGroot, Jack D ; Su, Yanli ; Koeman, Julie ; Dykema, Karl ; Leung, Samuel ; Snider, Jacqueline ; Davies, Sherri R ; Swiatek, Pamela J ; Cottingham, Sandra ; Watson, Mark A ; Ellis, Matthew J ; Sigler, Robert E ; Furge, Kyle A ; Vande Woude, George F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-d3e0db5453037feaf8766ce4c149accd9ac2eb7a74fa3b2cd3b728f91a2a2e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - etiology</topic><topic>Adenocarcinoma - genetics</topic><topic>Animals</topic><topic>Basal cell carcinoma</topic><topic>Biological Sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - genetics</topic><topic>Breasts</topic><topic>Cancer</topic><topic>Correlation analysis</topic><topic>Female</topic><topic>Gene Amplification</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Laboratory staining techniques</topic><topic>Mammary Neoplasms, Experimental - etiology</topic><topic>Mammary Neoplasms, Experimental - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Oncogenes</topic><topic>Proto-Oncogene Proteins c-met - genetics</topic><topic>Proto-Oncogene Proteins c-met - physiology</topic><topic>Receptor, ErbB-2 - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Rodents</topic><topic>Signal Transduction</topic><topic>Signatures</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graveel, Carrie R</creatorcontrib><creatorcontrib>DeGroot, Jack D</creatorcontrib><creatorcontrib>Su, Yanli</creatorcontrib><creatorcontrib>Koeman, Julie</creatorcontrib><creatorcontrib>Dykema, Karl</creatorcontrib><creatorcontrib>Leung, Samuel</creatorcontrib><creatorcontrib>Snider, Jacqueline</creatorcontrib><creatorcontrib>Davies, Sherri R</creatorcontrib><creatorcontrib>Swiatek, Pamela J</creatorcontrib><creatorcontrib>Cottingham, Sandra</creatorcontrib><creatorcontrib>Watson, Mark A</creatorcontrib><creatorcontrib>Ellis, Matthew J</creatorcontrib><creatorcontrib>Sigler, Robert E</creatorcontrib><creatorcontrib>Furge, Kyle A</creatorcontrib><creatorcontrib>Vande Woude, George F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graveel, Carrie R</au><au>DeGroot, Jack D</au><au>Su, Yanli</au><au>Koeman, Julie</au><au>Dykema, Karl</au><au>Leung, Samuel</au><au>Snider, Jacqueline</au><au>Davies, Sherri R</au><au>Swiatek, Pamela J</au><au>Cottingham, Sandra</au><au>Watson, Mark A</au><au>Ellis, Matthew J</au><au>Sigler, Robert E</au><au>Furge, Kyle A</au><au>Vande Woude, George F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2009-08-04</date><risdate>2009</risdate><volume>106</volume><issue>31</issue><spage>12909</spage><epage>12914</epage><pages>12909-12914</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Metmut) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ERBB2 expression, and expression of cytokeratin 5. With gene expression and tissue microarray analysis, we show that high MET expression in human breast cancers significantly correlated with estrogen receptor negative/ERBB2 negative tumors and with basal breast cancers. Few treatment options exist for breast cancers of the basal or trastuzumab-resistant ERBB2 subtypes. We conclude from these studies that MET may play a critical role in the development of the most aggressive breast cancers and may be a rational therapeutic target.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>19567831</pmid><doi>10.1073/pnas.0810403106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (31), p.12909-12914 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2722304 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adenocarcinoma Adenocarcinoma - etiology Adenocarcinoma - genetics Animals Basal cell carcinoma Biological Sciences Breast cancer Breast Neoplasms - etiology Breast Neoplasms - genetics Breasts Cancer Correlation analysis Female Gene Amplification Gene expression Humans Immunohistochemistry Laboratory staining techniques Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - genetics Mice Mice, Inbred C57BL Oncogenes Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - physiology Receptor, ErbB-2 - analysis Receptors, Progesterone - analysis Rodents Signal Transduction Signatures Tumors |
| title | Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T12%3A49%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Met%20induces%20diverse%20mammary%20carcinomas%20in%20mice%20and%20is%20associated%20with%20human%20basal%20breast%20cancer&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Graveel,%20Carrie%20R&rft.date=2009-08-04&rft.volume=106&rft.issue=31&rft.spage=12909&rft.epage=12914&rft.pages=12909-12914&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0810403106&rft_dat=%3Cjstor_pubme%3E40484624%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201416022&rft_id=info:pmid/19567831&rft_jstor_id=40484624&rfr_iscdi=true |