Novel Acylphosphate Mimics that Target PlsY, an Essential Acyltransferase in Gram-Positive Bacteria

PlsY is a recently discovered acyltransferase that executes an essential step in membrane phospholipid biosynthesis in Gram-positive bacteria. Using a bioisosteric replacement approach to generate substrate-based inhibitors of PlsY as potential novel antibacterial agents, a series of stabilized acyl...

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Veröffentlicht in:	ChemMedChem 2008-12, Vol.3 (12), p.1936-1945
Hauptverfasser:	Grimes, Kimberly D., Lu, Ying-Jie, Zhang, Yong-Mei, Luna, Vicki A., Hurdle, Julian G., Carson, Elizabeth I., Qi, Jianjun, Kudrimoti, Sucheta, Rock, Charles O., Lee, Richard E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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