Build it up–Tear it down: protein quality control in the cardiac sarcomere

The assembly and maintenance of the cardiac sarcomere, which contains the basic contractile components of actin and myosin, are essential for cardiac function. While often described as a static structure, the sarcomere is actually dynamic and undergoes constant turnover, allowing it to adapt to phys...

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Veröffentlicht in:	Cardiovascular research 2009-02, Vol.81 (3), p.439-448
Hauptverfasser:	Willis, Monte S., Schisler, Jonathan C., Portbury, Andrea L., Patterson, Cam
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptation, Physiological alpha-Crystallin B Chain - metabolism Animals Atrogin-1 Autophagy C-terminal of Hsp70 interacting protein Caenorhabditis elegans Proteins - metabolism Calpain - metabolism Cardiomyopathies - metabolism Cardiomyopathies - physiopathology Chaperones Desmin - metabolism GimC HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism Humans MAFbx MDM2 Molecular Chaperones - metabolism Muscle Contraction Muscle Proteins - blood Muscle ring finger Myocardium - enzymology Myocardium - metabolism Myosins - metabolism Proteasome Proteasome Endopeptidase Complex - metabolism Protein quality control Reviews Sarcomeres - enzymology Sarcomeres - metabolism TriC Ubiquitin Ubiquitin - metabolism Ubiquitin ligase Ubiquitin-Protein Ligases - metabolism UNC-45 UPD-2 αB-crystallin
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