Combination of small interfering RNAs mediates greater suppression on hepatitis B virus cccDNA in HepG2.2.15 cells

AIM： To observe the inhibition of hepatitis B virus （HBV） replication and expression in HepG2.2.15 cells by combination of small interfering RNAs （siRNAs）. METHODS： Recombinant plasmid psiI-HBV was constructed and transfected into HepG2.2.15 cells. At 48 h, 72 h and 96 h after transfection, culture...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-06, Vol.14 (24), p.3849-3854
Hauptverfasser:	Xin, Xiao-Min, Li, Gui-Qiu, Jin, Ying-Yu, Zhuang, Min, Li, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Research Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - virology Cell Line, Tumor DNA DNA, Viral - drug effects DNA, Viral - metabolism Dose-Response Relationship, Drug Hepacivirus - genetics Hepacivirus - physiology Hepatitis B e Antigens - drug effects Hepatitis B e Antigens - metabolism Hepatitis B Surface Antigens - drug effects Hepatitis B Surface Antigens - metabolism Humans Liver Neoplasms - immunology Liver Neoplasms - metabolism Liver Neoplasms - virology Nucleic Acid Amplification Techniques Plasmids RNA, Messenger - metabolism RNA, Small Interfering - pharmacology RNAs RNA干扰 Transfection Virus Replication - drug effects 乙肝病毒
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