Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites
To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. The study was carried on 40 patients with liver cirrhosis and ascites treated wit...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2009-08, Vol.15 (29), p.3631-3635 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | El-Bokl, Mohammed Abdelhamid Senousy, Bahaa Eldeen El-Karmouty, Khaled Zakaria Mohammed, Inas El Khedr Mohammed, Sherif Monier Shabana, Sherif Sadek Shalaby, Hassan |
| description | To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics.
The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy. Patients were divided into two groups according to 24-h urinary sodium. We measured spot urine Na/K ratio, Na/Cr ratio and 24-h urinary sodium. Student's t test was used to compare the interval variables and chi(2) test to compare the nominal variables between the two groups. Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio.
The best cutoff point for Na/K ratio was 2.5 (P < 0.001) and area under the curve (AUC) was 0.9, and for Na/Cr ratio, the best cutoff point was 35 (P < 0.001) and AUC was 0.885. Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio (87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively).
Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites. |
| doi_str_mv | 10.3748/wjg.15.3631 |
| format | Article |
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The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy. Patients were divided into two groups according to 24-h urinary sodium. We measured spot urine Na/K ratio, Na/Cr ratio and 24-h urinary sodium. Student's t test was used to compare the interval variables and chi(2) test to compare the nominal variables between the two groups. Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio.
The best cutoff point for Na/K ratio was 2.5 (P < 0.001) and area under the curve (AUC) was 0.9, and for Na/Cr ratio, the best cutoff point was 35 (P < 0.001) and AUC was 0.885. Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio (87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively).
Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.15.3631</identifier><identifier>PMID: 19653340</identifier><language>eng</language><publisher>United States: Department of Gastroenterology and Hepatology, Ain Shams University school of Medicine, Abbassia 11566, Cairo, Egypt</publisher><subject>Ascites - diet therapy ; Ascites - drug therapy ; Ascites - urine ; Brief ; Creatinine - urine ; Diet, Sodium-Restricted ; Diuretics - therapeutic use ; Female ; Humans ; Liver Cirrhosis - diet therapy ; Liver Cirrhosis - drug therapy ; Liver Cirrhosis - urine ; Male ; Middle Aged ; Patient Compliance ; Potassium - urine ; Sodium - urine ; Urinalysis - standards</subject><ispartof>World journal of gastroenterology : WJG, 2009-08, Vol.15 (29), p.3631-3635</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2009 The WJG Press and Baishideng. All rights reserved. 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-4377a511e9243dfaa8e8d5f9aa1074ec0eb8821c375bbc1ccafcf565a203053a3</citedby><cites>FETCH-LOGICAL-c475t-4377a511e9243dfaa8e8d5f9aa1074ec0eb8821c375bbc1ccafcf565a203053a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721236/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721236/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19653340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Bokl, Mohammed Abdelhamid</creatorcontrib><creatorcontrib>Senousy, Bahaa Eldeen</creatorcontrib><creatorcontrib>El-Karmouty, Khaled Zakaria</creatorcontrib><creatorcontrib>Mohammed, Inas El Khedr</creatorcontrib><creatorcontrib>Mohammed, Sherif Monier</creatorcontrib><creatorcontrib>Shabana, Sherif Sadek</creatorcontrib><creatorcontrib>Shalaby, Hassan</creatorcontrib><title>Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics.
The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy. Patients were divided into two groups according to 24-h urinary sodium. We measured spot urine Na/K ratio, Na/Cr ratio and 24-h urinary sodium. Student's t test was used to compare the interval variables and chi(2) test to compare the nominal variables between the two groups. Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio.
The best cutoff point for Na/K ratio was 2.5 (P < 0.001) and area under the curve (AUC) was 0.9, and for Na/Cr ratio, the best cutoff point was 35 (P < 0.001) and AUC was 0.885. Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio (87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively).
Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites.</description><subject>Ascites - diet therapy</subject><subject>Ascites - drug therapy</subject><subject>Ascites - urine</subject><subject>Brief</subject><subject>Creatinine - urine</subject><subject>Diet, Sodium-Restricted</subject><subject>Diuretics - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Cirrhosis - diet therapy</subject><subject>Liver Cirrhosis - drug therapy</subject><subject>Liver Cirrhosis - urine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Compliance</subject><subject>Potassium - urine</subject><subject>Sodium - urine</subject><subject>Urinalysis - standards</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLAzEUhYMotlZX7mUWgguZmsekmdkIUnxBQURdh0wmmaZMk5pkLP57U1q0ru7ifjn35BwAzhEcE1aUN-tFO0Z0TCYEHYAhxqjKcVnAQzBEELK8IpgNwEkICwgxIRQfgwGqJpSQAg7B69vKxaz3xgr_nQXXmH6ZaeczEYIKwdg2a4yKe0uvQvRGRuNsZmwmjfdzF41ML6SJKpyCIy26oM52cwQ-Hu7fp0_57OXxeXo3y2XBaMwLwpigCKkKF6TRQpSqbKiuhECQFUpCVZclRpIwWtcSSSm01HRCBYYEUiLICNxudVd9vVSNVDZ60fGVN8vkljth-P-NNXPeui-OGUY4pTUCl1uBtbBa2JYvXO9tssxTohjCClcpv4Rd7e5499mnz_OlCVJ1nbDK9YGzlCmjRQkTeb0lpXcheKV_zSDIN1VthDmifFNVoi_2_f-xu27ID69LkZA</recordid><startdate>20090807</startdate><enddate>20090807</enddate><creator>El-Bokl, Mohammed Abdelhamid</creator><creator>Senousy, Bahaa Eldeen</creator><creator>El-Karmouty, Khaled Zakaria</creator><creator>Mohammed, Inas El Khedr</creator><creator>Mohammed, Sherif Monier</creator><creator>Shabana, Sherif Sadek</creator><creator>Shalaby, Hassan</creator><general>Department of Gastroenterology and Hepatology, Ain Shams University school of Medicine, Abbassia 11566, Cairo, Egypt</general><general>The WJG Press and Baishideng</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20090807</creationdate><title>Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites</title><author>El-Bokl, Mohammed Abdelhamid ; Senousy, Bahaa Eldeen ; El-Karmouty, Khaled Zakaria ; Mohammed, Inas El Khedr ; Mohammed, Sherif Monier ; Shabana, Sherif Sadek ; Shalaby, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-4377a511e9243dfaa8e8d5f9aa1074ec0eb8821c375bbc1ccafcf565a203053a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Ascites - diet therapy</topic><topic>Ascites - drug therapy</topic><topic>Ascites - urine</topic><topic>Brief</topic><topic>Creatinine - urine</topic><topic>Diet, Sodium-Restricted</topic><topic>Diuretics - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Cirrhosis - diet therapy</topic><topic>Liver Cirrhosis - drug therapy</topic><topic>Liver Cirrhosis - urine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Compliance</topic><topic>Potassium - urine</topic><topic>Sodium - urine</topic><topic>Urinalysis - standards</topic><toplevel>online_resources</toplevel><creatorcontrib>El-Bokl, Mohammed Abdelhamid</creatorcontrib><creatorcontrib>Senousy, Bahaa Eldeen</creatorcontrib><creatorcontrib>El-Karmouty, Khaled Zakaria</creatorcontrib><creatorcontrib>Mohammed, Inas El Khedr</creatorcontrib><creatorcontrib>Mohammed, Sherif Monier</creatorcontrib><creatorcontrib>Shabana, Sherif Sadek</creatorcontrib><creatorcontrib>Shalaby, Hassan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Bokl, Mohammed Abdelhamid</au><au>Senousy, Bahaa Eldeen</au><au>El-Karmouty, Khaled Zakaria</au><au>Mohammed, Inas El Khedr</au><au>Mohammed, Sherif Monier</au><au>Shabana, Sherif Sadek</au><au>Shalaby, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2009-08-07</date><risdate>2009</risdate><volume>15</volume><issue>29</issue><spage>3631</spage><epage>3635</epage><pages>3631-3635</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To evaluate the accuracy of spot urinary Na/K and Na/creatinine (Cr) ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics.
The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy. Patients were divided into two groups according to 24-h urinary sodium. We measured spot urine Na/K ratio, Na/Cr ratio and 24-h urinary sodium. Student's t test was used to compare the interval variables and chi(2) test to compare the nominal variables between the two groups. Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio.
The best cutoff point for Na/K ratio was 2.5 (P < 0.001) and area under the curve (AUC) was 0.9, and for Na/Cr ratio, the best cutoff point was 35 (P < 0.001) and AUC was 0.885. Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio (87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively).
Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites.</abstract><cop>United States</cop><pub>Department of Gastroenterology and Hepatology, Ain Shams University school of Medicine, Abbassia 11566, Cairo, Egypt</pub><pmid>19653340</pmid><doi>10.3748/wjg.15.3631</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2009-08, Vol.15 (29), p.3631-3635 |
| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Ascites - diet therapy Ascites - drug therapy Ascites - urine Brief Creatinine - urine Diet, Sodium-Restricted Diuretics - therapeutic use Female Humans Liver Cirrhosis - diet therapy Liver Cirrhosis - drug therapy Liver Cirrhosis - urine Male Middle Aged Patient Compliance Potassium - urine Sodium - urine Urinalysis - standards |
| title | Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites |
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