Hexosamine Template. A Platform for Modulating Gene Expression and for Sugar-Based Drug Discovery

This study investigates the breadth of cellular responses engendered by short chain fatty acid (SCFA)−hexosamine hybrid molecules, a class of compounds long used in “metabolic glycoengineering” that are now emerging as drug candidates. First, a “mix and match” strategy showed that different SCFA (n-...

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Veröffentlicht in:	Journal of medicinal chemistry 2009-04, Vol.52 (8), p.2515-2530
Hauptverfasser:	Elmouelhi, Noha, Aich, Udayanath, Paruchuri, Venkata D. P, Meledeo, M. Adam, Campbell, Christopher T, Wang, Jean J, Srinivas, Raja, Khanna, Hargun S, Yarema, Kevin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Apoptosis Cell Line, Tumor Cell Proliferation - drug effects Drug Discovery Early Growth Response Protein 1 - biosynthesis Early Growth Response Protein 1 - genetics Fatty Acids, Volatile - chemical synthesis Fatty Acids, Volatile - chemistry Fatty Acids, Volatile - pharmacology Gene Expression - drug effects Gene Expression Profiling Glucuronidase - biosynthesis Glucuronidase - genetics Hexosamines - chemical synthesis Hexosamines - chemistry Hexosamines - pharmacology Humans Models, Molecular Mucin-1 - biosynthesis N-Acetylneuraminic Acid - biosynthesis NF-kappa B - biosynthesis NF-kappa B - genetics Oligonucleotide Array Sequence Analysis Oncogenes Signal Transduction Structure-Activity Relationship Transcription, Genetic Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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