SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap
The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on...
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| Veröffentlicht in: | Bioinformatics 2008-12, Vol.24 (24), p.2938-2939 |
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| container_title | Bioinformatics |
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| creator | Johnson, Andrew D. Handsaker, Robert E. Pulit, Sara L. Nizzari, Marcia M. O'Donnell, Christopher J. de Bakker, Paul I. W. |
| description | The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies). Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/. Contact: debakker@broad.mit.edu |
| doi_str_mv | 10.1093/bioinformatics/btn564 |
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W.</creator><creatorcontrib>Johnson, Andrew D. ; Handsaker, Robert E. ; Pulit, Sara L. ; Nizzari, Marcia M. ; O'Donnell, Christopher J. ; de Bakker, Paul I. W.</creatorcontrib><description>The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies). Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/. 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For Permissions, please email: journals.permissions@oxfordjournals.org 2008</rights><rights>2009 INIST-CNRS</rights><rights>The Author 2008. Published by Oxford University Press. All rights reserved. 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W.</creatorcontrib><title>SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap</title><title>Bioinformatics</title><addtitle>Bioinformatics</addtitle><description>The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies). Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/. Contact: debakker@broad.mit.edu</description><subject>Applications Note</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genome, Human</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Internet</subject><subject>Linkage Disequilibrium</subject><subject>Mathematics in biology. Statistical analysis. Models. Metrology. 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| source | Oxford Journals Open Access Collection |
| subjects | Applications Note Biological and medical sciences Fundamental and applied biological sciences. Psychology General aspects Genome, Human Genome-Wide Association Study Genotype Humans Internet Linkage Disequilibrium Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Polymorphism, Single Nucleotide - genetics Software |
| title | SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap |
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