Quantitation of Aurora Kinase A Gene Copy Number in Urine Sediments and Bladder Cancer Detection

Background Chromosome missegregation and the resulting aneuploidy is a common change in neoplasia. The Aurora kinase A (AURKA) gene, which encodes a key regulator of mitosis, is frequently amplified and/or overexpressed in cancer cells, and the level of AURKA amplification is associated with the lev...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2008-10, Vol.100 (19), p.1401-1411
Hauptverfasser:	Park, Hong-Seok, Park, Weon Seo, Bondaruk, Jolanta, Tanaka, Noriyoshi, Katayama, Hiroshi, Lee, Sangkyou, Spiess, Philippe E., Steinberg, Jordan R., Wang, Zhi, Katz, Ruth L., Dinney, Colin, Elias, Keren J., Lotan, Yair, Naeem, Rizwan C., Baggerly, Keith, Sen, Subrata, Grossman, H. Barton, Czerniak, Bogdan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Aurora Kinase A Aurora Kinases Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - urine Bladder cancer Cancer Carcinoma in Situ - diagnosis Carcinoma in Situ - genetics Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - enzymology Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - surgery Carcinoma, Transitional Cell - urine Cell Line, Tumor Cystectomy Diagnosis, Differential DNA, Neoplasm - genetics DNA, Neoplasm - urine Gene Amplification Gene expression Gene Expression Regulation, Neoplastic Green Fluorescent Proteins Humans Immunohistochemistry In Situ Hybridization, Fluorescence Kinases Medical diagnosis Medical sciences Nephrology. Urinary tract diseases Oncology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - urine Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Transfection Tumors Tumors of the urinary system Up-Regulation Urinalysis Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - surgery Urinary Bladder Neoplasms - urine Urinary tract. Prostate gland Urogenital system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!