Exploring the folate pathway in Plasmodium falciparum

As in centuries past, the main weapon against human malaria infections continues to be intervention with drugs, despite the widespread and increasing frequency of parasite populations that are resistant to one or more of the available compounds. This is a particular problem with the lethal species o...

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Veröffentlicht in:	Acta tropica 2005-06, Vol.94 (3), p.191-206
1. Verfasser:	Hyde, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifolate drugs Dihydropteroate Synthase - metabolism Drug Resistance Folate metabolism Folate salvage Folic Acid Antagonists - pharmacology Folic Acid Antagonists - therapeutic use Gene disruption Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Metabolic labelling Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Tetrahydrofolate Dehydrogenase - metabolism
Online-Zugang:	Volltext
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