Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients

Treg deficiencies are associated with autoimmunity. Conversely, CD4+ and CD8+ Tregs accumulate in the tumor microenvironment and are associated with prevention of antitumor immunity and anticancer immunotherapy. Recently, CD4+ Tregs have been much studied, but little is known about CD8+ Tregs and th...

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Veröffentlicht in:	The Journal of clinical investigation 2009-08, Vol.119 (8), p.2245-2256
Hauptverfasser:	Andersen, Mads Hald, Sørensen, Rikke Baek, Brimnes, Marie K, Svane, Inge Marie, Becker, Jürgen C, thor Straten, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	CD8-Positive T-Lymphocytes - immunology Heme Oxygenase-1 - immunology HLA-A2 Antigen - immunology Humans Immunophenotyping Interferon-gamma - biosynthesis Interleukin-10 - biosynthesis Lymphocyte Activation Neoplasms - immunology T-Lymphocytes, Regulatory - immunology
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