Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission

Previous research has suggested that mobilization of neurotrophic factors, such as insulin-like growth factor I (IGF-I), can be involved in the effects of antidepressant treatments. The current experiments showed that IGF-I leads to antidepressant-like effects in the modified rat forced swim test wh...

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Veröffentlicht in:	European journal of pharmacology 2008-10, Vol.594 (1), p.109-116
Hauptverfasser:	Hoshaw, Brian A., Hill, Tiffany I., Crowley, James J., Malberg, Jessica E., Khawaja, Xavier, Rosenzweig-Lipson, Sharon, Schechter, Lee E., Lucki, Irwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animal model Animals Antidepressive Agents Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Binding, Competitive - drug effects Biological and medical sciences Cell Proliferation - drug effects Citalopram - metabolism Dentate Gyrus - cytology Dentate Gyrus - drug effects Depression Desipramine - pharmacology Forced swim test Hippocampus - drug effects Hippocampus - metabolism Insulin-Like Growth Factor I - pharmacology Male Medical sciences Mood disorders Nerve Growth Factors - pharmacology Neurogenesis Neurotrophin Paroxetine - pharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rat Rats Rats, Sprague-Dawley Receptor, IGF Type 1 - drug effects RNA, Messenger - biosynthesis Serotonin - physiology Serotonin Uptake Inhibitors - metabolism Swimming - psychology Synaptic Transmission - drug effects Tryptophan Hydroxylase - metabolism
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