Novel roles of hakai in cell proliferation and oncogenesis

During tumor development, cells acquire multiple phenotypic changes upon misregulation of oncoproteins and tumor suppressor proteins. Hakai was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex that regulates cell-cell contacts. Here, we present evidence that Hakai plays a c...

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Veröffentlicht in:	Molecular biology of the cell 2009-08, Vol.20 (15), p.3533-3542
Hauptverfasser:	Figueroa, Angélica, Kotani, Hirokazu, Toda, Yoshinobu, Mazan-Mamczarz, Krystyna, Mueller, Eva-Christina, Otto, Albrecht, Disch, Lena, Norman, Mark, Ramdasi, Rasika Mohan, Keshtgar, Mohammed, Gorospe, Myriam, Fujita, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cadherins - genetics Cadherins - metabolism Cell Adhesion Cell Line Cell Line, Tumor Cell Proliferation Endometrium - metabolism Female Flow Cytometry Fluorescent Antibody Technique Humans Immunohistochemistry Lymph Nodes - metabolism Mice Mutation Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology NIH 3T3 Cells Oligonucleotide Array Sequence Analysis Protein Binding PTB-Associated Splicing Factor RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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