Structure of PhnP, a Phosphodiesterase of the Carbon-Phosphorus Lyase Pathway for Phosphonate Degradation

Carbon-phosphorus lyase is a multienzyme system encoded by the phn operon that enables bacteria to metabolize organophosphonates when the preferred nutrient, inorganic phosphate, is scarce. One of the enzymes encoded by this operon, PhnP, is predicted by sequence homology to be a metal-dependent hyd...

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Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (25), p.17216-17226
Hauptverfasser:	Podzelinska, Kateryna, He, Shu-Mei, Wathier, Matthew, Yakunin, Alexander, Proudfoot, Michael, Hove-Jensen, Bjarne, Zechel, David L., Jia, Zongchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Base Sequence Binding Sites Catalytic Domain Crystallography, X-Ray DNA Primers - genetics Enzyme Catalysis and Regulation Enzyme Stability Escherichia coli - enzymology Escherichia coli - genetics Kinetics Lyases - chemistry Lyases - genetics Lyases - metabolism Models, Molecular Molecular Sequence Data Multienzyme Complexes - chemistry Multienzyme Complexes - genetics Multienzyme Complexes - metabolism Mutagenesis, Site-Directed Organophosphonates - metabolism Phosphoric Diester Hydrolases - chemistry Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Protein Conformation Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Substrate Specificity Zinc - metabolism
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