A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases

G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated GPCRs and initiate their desensitization. Many prior studies suggest that activated GPCRs dock to an allosteric site on the GRKs and thereby stimulate kinase activity. The extreme N-terminal region of GRKs is clearly involved i...

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Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (25), p.17206-17215
Hauptverfasser:	Huang, Chih-chin, Yoshino-Koh, Kae, Tesmer, John J.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Allosteric Site Amino Acid Sequence Animals Cattle Enzyme Activation G-Protein-Coupled Receptor Kinase 2 - chemistry G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 2 - metabolism G-Protein-Coupled Receptor Kinases - chemistry G-Protein-Coupled Receptor Kinases - genetics G-Protein-Coupled Receptor Kinases - metabolism Humans In Vitro Techniques Kinetics Mechanisms of Signal Transduction Models, Biological Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Peptides - chemistry Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Substrate Specificity
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