Latent Transforming Growth Factor β-binding Proteins and Fibulins Compete for Fibrillin-1 and Exhibit Exquisite Specificities in Binding Sites

Latent transforming growth factor (TGF) β-binding proteins (LTBPs) interact with fibrillin-1. This interaction is important for proper sequestration and extracellular control of TGFβ. Surface plasmon resonance interaction studies show that residues within the first hybrid domain (Hyb1) of fibrillin-...

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Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (25), p.16872-16881
Hauptverfasser:	Ono, Robert N., Sengle, Gerhard, Charbonneau, Noe L., Carlberg, Valerie, Bächinger, Hans Peter, Sasaki, Takako, Lee-Arteaga, Sui, Zilberberg, Lior, Rifkin, Daniel B., Ramirez, Francesco, Chu, Mon-Li, Sakai, Lynn Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Binding, Competitive Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - deficiency Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cells, Cultured Extracellular Matrix Proteins - chemistry Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fibrillin-1 Fibrillins Genomics, Proteomics, and Bioinformatics Humans Latent TGF-beta Binding Proteins - genetics Latent TGF-beta Binding Proteins - metabolism Mice Mice, Knockout Microfibrils - metabolism Microfilament Proteins - chemistry Microfilament Proteins - deficiency Microfilament Proteins - genetics Microfilament Proteins - metabolism Protein Structure, Tertiary Recombinant Proteins - genetics Recombinant Proteins - metabolism Surface Plasmon Resonance
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