Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles
Purpose To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Methods Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipi...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2009-05, Vol.26 (5), p.243-249 |
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| creator | Barker, Matthew A. Boehnlein, Lynn M. Kovacs, Peter Lindheim, Steven R. |
| description | Purpose
To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
Methods
Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
Results
Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
Conclusions
Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes. |
| doi_str_mv | 10.1007/s10815-009-9312-z |
| format | Article |
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To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
Methods
Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
Results
Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
Conclusions
Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-009-9312-z</identifier><identifier>PMID: 19548081</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Assisted Reproduction ; Blastocyst - pathology ; Chorionic Gonadotropin - metabolism ; Embryos ; Endometrium ; Endometrium - pathology ; Estrogens - blood ; Female ; Follicular Phase ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Luteal Phase ; Medicine ; Medicine & Public Health ; Obstetrics ; Oocyte Donation ; Oocytes - cytology ; Ovaries ; Ovulation Induction ; Pregnancy ; Pregnancy Outcome ; Progesterone - blood ; Reproductive Medicine ; Sperm</subject><ispartof>Journal of assisted reproduction and genetics, 2009-05, Vol.26 (5), p.243-249</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-93551c38e3e41017d5b98badd1b78c0652a72c14227ea7fc915a4b53016d455a3</citedby><cites>FETCH-LOGICAL-c498t-93551c38e3e41017d5b98badd1b78c0652a72c14227ea7fc915a4b53016d455a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719070/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719070/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19548081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Matthew A.</creatorcontrib><creatorcontrib>Boehnlein, Lynn M.</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Lindheim, Steven R.</creatorcontrib><title>Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
Methods
Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
Results
Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
Conclusions
Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.</description><subject>Adult</subject><subject>Assisted Reproduction</subject><subject>Blastocyst - pathology</subject><subject>Chorionic Gonadotropin - metabolism</subject><subject>Embryos</subject><subject>Endometrium</subject><subject>Endometrium - pathology</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Follicular Phase</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Luteal Phase</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics</subject><subject>Oocyte Donation</subject><subject>Oocytes - cytology</subject><subject>Ovaries</subject><subject>Ovulation Induction</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Progesterone - blood</subject><subject>Reproductive Medicine</subject><subject>Sperm</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9v1DAQxSMEon_gA3BBFgduAY8dx84FCVW0IFXi0p4tx5nddfHawXaKtp8et7uigIQ42Zr5vTcev6Z5BfQdUCrfZ6AKREvp0A4cWHv3pDkGIXkrOadP650K1dKuV0fNSc43tIKK8efNEQyiU1V73Pw4j947u3iTiAkT8UtB48m8MRkJhilusSRXK2Xj7LeAOT9gaDdxjcFZMptSMIWH6pxwHUywOxKXYquUuEBitLuCZIrBFBcDsTvrMb9onq2Mz_jycJ421-efrs4-t5dfL76cfbxsbTeoUtcSAixXyLEDCnIS46BGM00wSmVpL5iRzELHmEQjV3YAYbpRcAr91Alh-GnzYe87L-MWJ4uhJOP1nNzWpJ2Oxuk_O8Ft9DreaiZhoJJWg7cHgxS_L5iL3rps0XsTMC5Z91J0wCX8F2SUcZC8r-Cbv8CbuKRQf0Ez6HsGHIYKwR6yKeaccPXryUD1ffh6H76umer78PVd1bz-fddHxSHtCrA9kGsrrDE9Tv6360_Sab0V</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Barker, Matthew A.</creator><creator>Boehnlein, Lynn M.</creator><creator>Kovacs, Peter</creator><creator>Lindheim, Steven R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090501</creationdate><title>Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles</title><author>Barker, Matthew A. ; Boehnlein, Lynn M. ; Kovacs, Peter ; Lindheim, Steven R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-93551c38e3e41017d5b98badd1b78c0652a72c14227ea7fc915a4b53016d455a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Assisted Reproduction</topic><topic>Blastocyst - pathology</topic><topic>Chorionic Gonadotropin - metabolism</topic><topic>Embryos</topic><topic>Endometrium</topic><topic>Endometrium - pathology</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Follicular Phase</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Luteal Phase</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics</topic><topic>Oocyte Donation</topic><topic>Oocytes - cytology</topic><topic>Ovaries</topic><topic>Ovulation Induction</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Progesterone - blood</topic><topic>Reproductive Medicine</topic><topic>Sperm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barker, Matthew A.</creatorcontrib><creatorcontrib>Boehnlein, Lynn M.</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Lindheim, Steven R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Matthew A.</au><au>Boehnlein, Lynn M.</au><au>Kovacs, Peter</au><au>Lindheim, Steven R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>26</volume><issue>5</issue><spage>243</spage><epage>249</epage><pages>243-249</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
Methods
Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
Results
Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
Conclusions
Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19548081</pmid><doi>10.1007/s10815-009-9312-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2009-05, Vol.26 (5), p.243-249 |
| issn | 1058-0468 1573-7330 |
| language | eng |
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| source | PubMed Central Free; MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Assisted Reproduction Blastocyst - pathology Chorionic Gonadotropin - metabolism Embryos Endometrium Endometrium - pathology Estrogens - blood Female Follicular Phase Gynecology Human Genetics Humans In vitro fertilization Luteal Phase Medicine Medicine & Public Health Obstetrics Oocyte Donation Oocytes - cytology Ovaries Ovulation Induction Pregnancy Pregnancy Outcome Progesterone - blood Reproductive Medicine Sperm |
| title | Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles |
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