Evaluation of candidate methylation markers to detect cervical neoplasia

Abstract Objective. Studies of cervical cancer and its immediate precursor, cervical intraepithelial neoplasia 3 (CIN3), have identified genes that often show aberrant DNA methylation and therefore represent candidate early detection markers. We used quantitative PCR assays to evaluate methylation i...

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Veröffentlicht in:	Gynecologic oncology 2007-12, Vol.107 (3), p.549-553
Hauptverfasser:	Shivapurkar, Narayan, Sherman, Mark E, Stastny, Victor, Echebiri, Chinyere, Rader, Janet S, Nayar, Ritu, Bonfiglio, Thomas A, Gazdar, Adi F, Wang, Sophia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Cadherins - genetics Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cervical cancer Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - pathology DNA Methylation Female Genes, Tumor Suppressor Genetic Markers - genetics Hematology, Oncology and Palliative Medicine Humans Obstetrics and Gynecology Polymerase Chain Reaction Promoter methylation Tumor suppressor genes Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology
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