Channelrhodopsin-2 is a leaky proton pump

Since its discovery, the light-gated cation channel Channelrhodopsin-2 (ChR2) has proven to be a long-sought tool for the noninvasive, light-activated control of neural cells in culture and in living animals. Although ChR2 is widely used in neurobiological applications, little is known about its mol...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-07, Vol.106 (30), p.12317-12322
Hauptverfasser:	Feldbauer, Katrin, Zimmermann, Dirk, Pintschovius, Verena, Spitz, Julia, Bamann, Christian, Bamberg, Ernst
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic spectra Amino acids Biological Sciences Carrier Proteins - genetics Carrier Proteins - physiology Cell culture Cell Line Cells Channel noise Dose-Response Relationship, Drug Electric current Electric potential Guanidine - pharmacology HEK293 cells Humans Ion channels Ion Channels - genetics Ion Channels - physiology Ions Kinetics Light Luminous intensity Membrane Potentials - drug effects Membrane Potentials - radiation effects Membranes Molecules Neurons Noise Patch-Clamp Techniques Proton Pumps - genetics Proton Pumps - physiology Protons Pumps Sodium Chloride - pharmacology Temperature Transfection
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