Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner

Chorismate mutase catalyzes a key step in the shikimate biosynthetic pathway towards phenylalanine and tyrosine. Curiously, the intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activity and lacks prominent active‐site residues. However, its catalytic efficiency...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 2009-07, Vol.28 (14), p.2128-2142
Hauptverfasser:	Sasso, Severin, Ökvist, Mats, Roderer, Kathrin, Gamper, Marianne, Codoni, Giosiana, Krengel, Ute, Kast, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Deoxy-7-Phosphoheptulonate Synthase - chemistry 3-Deoxy-7-Phosphoheptulonate Synthase - metabolism Actinomycetales Amino Acid Sequence Biochemistry Catalysis Catalytic Domain Cellular biology Chorismate Mutase - chemistry Chorismate Mutase - genetics Chorismate Mutase - metabolism Cloning, Molecular Corynebacterium glutamicum - enzymology Crystal structure Crystallography, X-Ray EMBO23 EMBO40 Enzyme Activation enzyme catalysis Enzymes Malates - chemistry Models, Molecular Molecular biology Molecular Sequence Data multi-enzyme complex Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis Rv0948c Phenylalanine - metabolism Residues Sequence Alignment shikimate pathway Shikimic Acid - metabolism Tuberculosis Tyrosine - metabolism X-ray crystal structure
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!