Gastric Mammalian Target of Rapamycin Signaling Regulates Ghrelin Production and Food Intake

Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate food intake. Mammalian target of rapamycin (mTOR) is an intracellular fuel sensor critical for cellular energy homeostasis. Here we showed the reciprocal relationship of gastric mTOR signaling and ghrelin...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-08, Vol.150 (8), p.3637-3644
Hauptverfasser:	Xu, Geyang, Li, Yin, An, Wenjiao, Li, Shenduo, Guan, Youfei, Wang, Nanping, Tang, Chaoshu, Wang, Xian, Zhu, Yi, Li, Xiaoying, Mulholland, Michael W, Zhang, Weizhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Central nervous system Eating - drug effects Eating - genetics Energy balance Energy intake Fasting - physiology Food intake Fuels Fundamental and applied biological sciences. Psychology Gastric Mucosa - metabolism Gene expression Gene Expression Regulation Ghrelin Ghrelin - genetics Ghrelin - metabolism Growth hormones Homeostasis Hunger Immunohistochemistry Intracellular signalling Leucine Leucine - pharmacology Male Mammals Mice Mice, Inbred C57BL Mice, Obese mRNA Obesity - physiopathology Polymerase Chain Reaction Promoter Regions, Genetic - drug effects Protein Kinases - metabolism Protein Kinases - physiology Rapamycin Receptors, Ghrelin - antagonists & inhibitors Receptors, Ghrelin - physiology Signal Transduction - drug effects Sirolimus - pharmacology TOR protein TOR Serine-Threonine Kinases Vertebrates: endocrinology
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