Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) Functions to Promote Uterine Decidual Angiogenesis during Early Pregnancy in the Mouse

Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-08, Vol.150 (8), p.3845-3854
Hauptverfasser:	Douglas, Nataki C, Tang, Hongyan, Gomez, Raul, Pytowski, Bronislaw, Hicklin, Daniel J, Sauer, Christopher M, Kitajewski, Jan, Sauer, Mark V, Zimmermann, Ralf C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies Antibodies, Monoclonal - pharmacology Apoptosis Biological and medical sciences Blocking antibodies Cell differentiation Cell Proliferation Deactivation Decidua Decidua - blood supply Decidua - drug effects Decidua - metabolism Embryogenesis Embryonic Development - drug effects Embryonic Development - physiology Embryos Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Growth factors Immunohistochemistry Implantation Inactivation Male Mice Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Ovariectomy Ovaries Physiological effects Placenta Pregnancy Progesterone Receptor mechanisms Receptors Reproductive status Reverse Transcriptase Polymerase Chain Reaction Stromal cells Uterus Uterus - drug effects Uterus - metabolism Vascular endothelial growth factor Vascular endothelial growth factor receptor 2 Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-1 - physiology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Endothelial Growth Factor Receptor-2 - physiology Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-3 - metabolism Vascular Endothelial Growth Factor Receptor-3 - physiology Vascular endothelial growth factor receptors Vertebrates: endocrinology
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