crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding

Cartilage oligomeric matrix protein (COMP), or thrombospondin-5 (TSP-5), is a secreted glycoprotein that is important for growth plate organization and function. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1). In this study, we...

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Veröffentlicht in:	The FASEB journal 2009-08, Vol.23 (8), p.2490-2501
Hauptverfasser:	Tan, Kemin, Duquette, Mark, Joachimiak, Andrzej, Lawler, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites Cartilage Oligomeric Matrix Protein Collagen - metabolism Crystallography, X-Ray Cysteine - chemistry DNA, Complementary - genetics Extracellular Matrix Proteins - chemistry Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Glycoproteins - chemistry Glycoproteins - genetics Glycoproteins - metabolism Glycosaminoglycans - metabolism Humans In Vitro Techniques Integrins - metabolism Ligands Matrilin Proteins Models, Molecular multiple epiphyseal dysplasia Mutation Oligopeptides - chemistry Protein Binding Protein Structure, Tertiary pseudoachondroplasia Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Research Communications Static Electricity Thrombospondin 1 - chemistry thrombospondins Thrombospondins - chemistry
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