Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation

Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of Ars2 is developmentally letha...

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Veröffentlicht in:	Cell 2009-07, Vol.138 (2), p.328-339
Hauptverfasser:	Gruber, Joshua J., Zatechka, D. Steven, Sabin, Leah R., Yong, Jeongsik, Lum, Julian J., Kong, Mei, Zong, Wei-Xing, Zhang, Zhenxi, Lau, Chi-Kong, Rawlings, Jason, Cherry, Sara, Ihle, James N., Dreyfuss, Gideon, Thompson, Craig B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic - toxicity Cell Line Cell Proliferation CELLCYCLE Guanosine - analogs & derivatives Guanosine - metabolism Humans Mice MicroRNAs Nuclear Cap-Binding Protein Complex - metabolism Nuclear Proteins - metabolism RNA RNA Interference
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