Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation
Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of Ars2 is developmentally letha...
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| Veröffentlicht in: | Cell 2009-07, Vol.138 (2), p.328-339 |
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| creator | Gruber, Joshua J. Zatechka, D. Steven Sabin, Leah R. Yong, Jeongsik Lum, Julian J. Kong, Mei Zong, Wei-Xing Zhang, Zhenxi Lau, Chi-Kong Rawlings, Jason Cherry, Sara Ihle, James N. Dreyfuss, Gideon Thompson, Craig B. |
| description | Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of
Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation. |
| doi_str_mv | 10.1016/j.cell.2009.04.046 |
| format | Article |
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Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/j.cell.2009.04.046</identifier><identifier>PMID: 19632182</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Arsenic - toxicity ; Cell Line ; Cell Proliferation ; CELLCYCLE ; Guanosine - analogs & derivatives ; Guanosine - metabolism ; Humans ; Mice ; MicroRNAs ; Nuclear Cap-Binding Protein Complex - metabolism ; Nuclear Proteins - metabolism ; RNA ; RNA Interference</subject><ispartof>Cell, 2009-07, Vol.138 (2), p.328-339</ispartof><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-3baea2cf3afb835beeb315c10ef125e9b76b97e68993a0c28505173c72eb1a333</citedby><cites>FETCH-LOGICAL-c550t-3baea2cf3afb835beeb315c10ef125e9b76b97e68993a0c28505173c72eb1a333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867409005078$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19632182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruber, Joshua J.</creatorcontrib><creatorcontrib>Zatechka, D. Steven</creatorcontrib><creatorcontrib>Sabin, Leah R.</creatorcontrib><creatorcontrib>Yong, Jeongsik</creatorcontrib><creatorcontrib>Lum, Julian J.</creatorcontrib><creatorcontrib>Kong, Mei</creatorcontrib><creatorcontrib>Zong, Wei-Xing</creatorcontrib><creatorcontrib>Zhang, Zhenxi</creatorcontrib><creatorcontrib>Lau, Chi-Kong</creatorcontrib><creatorcontrib>Rawlings, Jason</creatorcontrib><creatorcontrib>Cherry, Sara</creatorcontrib><creatorcontrib>Ihle, James N.</creatorcontrib><creatorcontrib>Dreyfuss, Gideon</creatorcontrib><creatorcontrib>Thompson, Craig B.</creatorcontrib><title>Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation</title><title>Cell</title><addtitle>Cell</addtitle><description>Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of
Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.</description><subject>Animals</subject><subject>Arsenic - toxicity</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>CELLCYCLE</subject><subject>Guanosine - analogs & derivatives</subject><subject>Guanosine - metabolism</subject><subject>Humans</subject><subject>Mice</subject><subject>MicroRNAs</subject><subject>Nuclear Cap-Binding Protein Complex - metabolism</subject><subject>Nuclear Proteins - metabolism</subject><subject>RNA</subject><subject>RNA Interference</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ud9rFDEQDmKx19N_wAfJk297TpLNZhdEOBethaOK2OeQzc62OfeSM9kr9r83yx3avggDAzPfj-EbQl4zWDFg1bvtyuI4rjhAs4IyV_WMLBg0qiiZ4s_JIi94UVeqPCcXKW0BoJZSviDnrKkEZzVfkJt1TJxunP-Z6HSH9PpgRzSRtmZffHS-d_6WtmG3H_E3nQL9fr2mV37COGBEb5Ea39M2X0G_xTC6PDWTC_4lORvMmPDVqS_JzedPP9ovxebr5VW73hRWSpgK0Rk03A7CDF0tZIfYCSYtAxwYl9h0quoahVXdNMKA5bUEyZSwimPHjBBiST4cdfeHboe9RT9FM-p9dDsTH3QwTj_deHenb8O95oopEGUWeHsSiOHXAdOkdy7NqRqP4ZA0Z1CVZbZfEn4E2hhSijj8NWGg52_orZ55ev6GhjJXlUlvHp_3j3KKPwPeHwGYQ7p3GHWybs61dxHtpPvg_qf_B7GBnCU</recordid><startdate>20090723</startdate><enddate>20090723</enddate><creator>Gruber, Joshua J.</creator><creator>Zatechka, D. 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Steven</au><au>Sabin, Leah R.</au><au>Yong, Jeongsik</au><au>Lum, Julian J.</au><au>Kong, Mei</au><au>Zong, Wei-Xing</au><au>Zhang, Zhenxi</au><au>Lau, Chi-Kong</au><au>Rawlings, Jason</au><au>Cherry, Sara</au><au>Ihle, James N.</au><au>Dreyfuss, Gideon</au><au>Thompson, Craig B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2009-07-23</date><risdate>2009</risdate><volume>138</volume><issue>2</issue><spage>328</spage><epage>339</epage><pages>328-339</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of
Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19632182</pmid><doi>10.1016/j.cell.2009.04.046</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Arsenic - toxicity Cell Line Cell Proliferation CELLCYCLE Guanosine - analogs & derivatives Guanosine - metabolism Humans Mice MicroRNAs Nuclear Cap-Binding Protein Complex - metabolism Nuclear Proteins - metabolism RNA RNA Interference |
| title | Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation |
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