Sculpting the Proteome with AAA+ Proteases and Disassembly Machines
Machines of protein destruction—including energy-dependent proteases and disassembly chaperones of the AAA+ ATPase family—function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change...
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| Veröffentlicht in: | Cell 2004-10, Vol.119 (1), p.9-18 |
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| container_title | Cell |
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| creator | Sauer, Robert T. Bolon, Daniel N. Burton, Briana M. Burton, Randall E. Flynn, Julia M. Grant, Robert A. Hersch, Greg L. Joshi, Shilpa A. Kenniston, Jon A. Levchenko, Igor Neher, Saskia B. Oakes, Elizabeth S.C. Siddiqui, Samia M. Wah, David A. Baker, Tania A. |
| description | Machines of protein destruction—including energy-dependent proteases and disassembly chaperones of the AAA+ ATPase family—function in all kingdoms of life to sculpt the cellular proteome, ensuring that unnecessary and dangerous proteins are eliminated and biological responses to environmental change are rapidly and properly regulated. Exciting progress has been made in understanding how AAA+ machines recognize specific proteins as targets and then carry out ATP-dependent dismantling of the tertiary and/or quaternary structure of these molecules during the processes of protein degradation and the disassembly of macromolecular complexes. |
| doi_str_mv | 10.1016/j.cell.2004.09.020 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adaptor Proteins, Vesicular Transport - genetics Adaptor Proteins, Vesicular Transport - metabolism Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Animals Binding Sites - physiology Humans Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular Conformation Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Proteome - genetics Proteome - metabolism |
| title | Sculpting the Proteome with AAA+ Proteases and Disassembly Machines |
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