Activation of mTORC1 Signaling Pathway in AIDS-Related Lymphomas

Using immunohistochemistry with antibodies against the phosphoserine residues in both S6rp and 4E binding protein 1, we identified the activation of the mammalian target of rapamycin (mTORC)1 pathway in 29 cases of AIDS-related lymphoma. These cases represented a diverse spectrum of histological typ...

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Veröffentlicht in:	The American journal of pathology 2009-08, Vol.175 (2), p.817-824
Hauptverfasser:	El-Salem, Mouna, Raghunath, Puthiyaveettil N, Marzec, Michal, Liu, Xiaobin, Kasprzycka, Monika, Robertson, Erle, Wasik, Mariusz A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Phospho-Specific - immunology Biological and medical sciences Hematologic and hematopoietic diseases Human viral diseases Humans Infectious diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, AIDS-Related - metabolism Lymphoma, AIDS-Related - pathology Mechanistic Target of Rapamycin Complex 1 Medical sciences Multiprotein Complexes Pathology Phosphoserine - analysis Phosphoserine - immunology Proteins Regular TOR Serine-Threonine Kinases Transcription Factors - analysis Transcription Factors - biosynthesis Transcription Factors - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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