Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas

PURPOSE Since activity of sorafenib was observed in sarcoma patients in a phase I study, we performed a multicenter phase II study of daily oral sorafenib in patients with recurrent or metastatic sarcoma. PATIENTS AND METHODS We employed a multiarm study design, each representing a sarcoma subtype w...

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Veröffentlicht in:	Journal of clinical oncology 2009-07, Vol.27 (19), p.3133-3140
Hauptverfasser:	MAKI, Robert G, D'ADAMO, David R, TAKIMOTO, Chris H, KRAFT, Andrew S, ELIAS, Anthony D, BROCKSTEIN, Bruce, BLACHERE, Nathalie E, EDGAR, Mark A, SCHWARTZ, Lawrence H, QIN, Li-Xuan, ANTONESCU, Cristina R, SCHWARTZ, Gary K, KEOHAN, Mary L, SAULLE, Michael, SCHUETZE, Scott M, UNDEVIA, Samir D, LIVINGSTON, Michael B, COONEY, Matthew M, HENSLEY, Martee L, MITA, Monica M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Benzenesulfonates - pharmacokinetics Benzenesulfonates - therapeutic use Biological and medical sciences Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Niacinamide - analogs & derivatives Original Reports Phenylurea Compounds Pyridines - pharmacokinetics Pyridines - therapeutic use Sarcoma - drug therapy Sarcoma - mortality Sorafenib Tumors Young Adult
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