Candesartan Augments Ischemia-Induced Proangiogenic State and Results in Sustained Improvement After Stroke

We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatm...

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Veröffentlicht in:	Stroke (1970) 2009-05, Vol.40 (5), p.1870-1876
Hauptverfasser:	KOZAK, Anna, ERGUL, Adviye, EL-REMESSY, Azza B, JOHNSON, Maribeth H, MACHADO, Livia S, ELEWA, Hazem F, ABDELSAID, Mohammed, WILEY, Daniel C, FAGAN, Susan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Behavior, Animal - physiology Benzimidazoles - pharmacology Biological and medical sciences Blood Pressure - physiology Body Weight - physiology Brain Ischemia - complications Brain Ischemia - drug therapy Brain Ischemia - psychology Capillary Permeability - drug effects Endothelial Cells - pathology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Infarction, Middle Cerebral Artery - pathology Laminin - metabolism Male Matrix Metalloproteinases - biosynthesis Medical sciences Microtubules - pathology Neovascularization, Physiologic - drug effects Nervous system (semeiology, syndromes) Neurology Rats Rats, Wistar Stroke - drug therapy Stroke - etiology Stroke - psychology Tetrazoles - pharmacology Vascular diseases and vascular malformations of the nervous system Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - metabolism
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