Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

Although technically feasible, whole-genome analysis of cytosine methylation using bisulfite sequencing remains prohibitively expensive for large eukaryotic genomes. Deng et al . use 30,000 nondegenerate padlock probes to capture ∼66,000 bisulfite-converted sites in human CpG islands and compare the...

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Veröffentlicht in:	Nature biotechnology 2009-04, Vol.27 (4), p.353-360
Hauptverfasser:	Hochedlinger, Konrad, Wang, Wei, Eggan, Kevin, LeProust, Emily M, Deng, Jie, Gore, Athurva, Gao, Yuan, Zhang, Kun, Xie, Bin, Shoemaker, Robert, Antosiewicz-Bourget, Jessica, Daley, George Q, Maherali, Nimet, Park, In-Hyun, Yu, Junying, Thomson, James, Egli, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Base Sequence Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Nucleus - genetics Chromosomes Deoxyribonucleic acid DNA DNA - chemistry DNA - genetics DNA Methylation - genetics DNA sequencing Fundamental and applied biological sciences. Psychology Gene Targeting - methods Genomics Humans Islands Life Sciences Metabolome - genetics Methylation Molecular Sequence Data Nucleotide sequencing Physiological aspects Probes Research methodology Sequence Analysis, DNA - methods Stem cells Sulfites
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