A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

A tissue-specific transcriptional enhancer, Emu, has been implicated in developmentally regulated recombination and transcription of the immunoglobulin heavy chain (IgH) gene locus. We demonstrate that deleting 220 nucleotides that constitute the core Emu results in partially active locus, character...

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Veröffentlicht in:	The Journal of experimental medicine 2009-05, Vol.206 (5), p.1019-1027
Hauptverfasser:	Chakraborty, Tirtha, Perlot, Thomas, Subrahmanyam, Ramesh, Jani, Anant, Goff, Peter H, Zhang, Yu, Ivanova, Irina, Alt, Frederick W, Sen, Ranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brief Definitive Report Cell Line Deoxyribonuclease I Enhancer Elements, Genetic Gene Expression Regulation - immunology Histones - genetics Immunoglobulin Heavy Chains - genetics Introns - genetics Mice Mice, Knockout Sequence Deletion T-Lymphocytes - immunology Transcription, Genetic
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