Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells

Despite the predominance of ultraviolet A (UVA) relative to UVB in terrestrial sunlight, solar mutagenesis in humans and rodents is characterized by mutations specific for UVB. We have investigated the kinetics of repair of UVA- and UVB-induced DNA lesions in relation to mutagenicity in transgenic m...

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Veröffentlicht in:	The FASEB journal 2008-07, Vol.22 (7), p.2379-2392
Hauptverfasser:	Besaratinia, Ahmad, Kim, Sang-in, Pfeifer, Gerd P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA damage DNA Damage - radiation effects DNA Repair - radiation effects Dose-Response Relationship, Radiation Embryo, Mammalian Genome - radiation effects Mice mutations Purines - radiation effects Pyrimidines - radiation effects skin cancer Sunlight - adverse effects ultraviolet radiation Ultraviolet Rays - adverse effects
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