Synergistic ototoxicity due to noise exposure and aminoglycoside antibiotics

Acoustic exposure to high intensity and/or prolonged noise causes temporary or permanent threshold shifts in auditory perception, reflected by reversible or irreversible damage in the cochlea. Aminoglycoside antibiotics, used for treating or preventing life-threatening bacterial infections, also ind...

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Veröffentlicht in:	Noise & health 2009-01, Vol.11 (42), p.26-32
Hauptverfasser:	Li, Hongzhe, Steyger, Peter S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aminoglycosides Aminoglycosides - adverse effects Aminoglycosides - toxicity Animal Experimentation Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - toxicity Antibiotics Apoptosis Auditory Threshold Bacterial diseases Care and treatment Cell Death Cochlea - drug effects Cochlea - pathology Cytotoxicity Diagnosis Drug dosages Ears & hearing Experiments Exposure Gentamicins - administration & dosage Gentamicins - adverse effects Gentamicins - toxicity Guinea Pigs Hair Hair Cells, Auditory - drug effects Health aspects Hearing disorders Hearing loss Hearing Loss - chemically induced Hearing Loss, Noise-Induced - complications Hearing protection Hospitals Humans Infant, Newborn Intensive Care Units, Neonatal Kanamycin - administration & dosage Kanamycin - adverse effects Kanamycin - toxicity Meningitis Mitochondria - drug effects Neomycin - administration & dosage Neomycin - adverse effects Neomycin - toxicity Noise Otoacoustic Emissions, Spontaneous Ototoxicity Reactive Oxygen Species Risk factors Substance abuse treatment Time Factors Toxicity
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