A preliminary study of functional connectivity in comorbid adolescent depression
Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the su...
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| Veröffentlicht in: | Neuroscience letters 2009-09, Vol.460 (3), p.227-231 |
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| creator | Cullen, Kathryn R. Gee, Dylan G. Klimes-Dougan, Bonnie Gabbay, Vilma Hulvershorn, Leslie Mueller, Bryon A. Camchong, Jazmin Bell, Christopher J. Houri, Alaa Kumra, Sanjiv Lim, Kelvin O. Castellanos, F. Xavier Milham, Michael P. |
| description | Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the subgenual anterior cingulate cortex (ACC). Developmental changes in brain networks during adolescence highlight the need to examine MDD-related circuitry in teens separately from adults. Using resting state functional magnetic resonance imaging (fMRI), this study examined functional connectivity in adolescents with MDD (
n
=
12) and healthy adolescents (
n
=
14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD. |
| doi_str_mv | 10.1016/j.neulet.2009.05.022 |
| format | Article |
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n
=
12) and healthy adolescents (
n
=
14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2009.05.022</identifier><identifier>PMID: 19446602</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescence ; Adolescent ; Amygdala - blood supply ; Amygdala - physiopathology ; Biological and medical sciences ; Brain imaging ; Brain Mapping ; Cerebral Cortex - blood supply ; Cerebral Cortex - physiopathology ; Depression ; Depressive Disorder, Major - physiopathology ; Echo-Planar Imaging ; Female ; Functional connectivity ; Fundamental and applied biological sciences. Psychology ; Gyrus Cinguli - blood supply ; Gyrus Cinguli - physiopathology ; Humans ; Male ; Nerve Net - physiopathology ; Resting state functional MRI ; Subgenual anterior cingulate cortex ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>Neuroscience letters, 2009-09, Vol.460 (3), p.227-231</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-e1e669f96d9d0dbc6586e5377b5a58352570e59a7b43205e873019a43a825b7a3</citedby><cites>FETCH-LOGICAL-c522t-e1e669f96d9d0dbc6586e5377b5a58352570e59a7b43205e873019a43a825b7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2009.05.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21723241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19446602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cullen, Kathryn R.</creatorcontrib><creatorcontrib>Gee, Dylan G.</creatorcontrib><creatorcontrib>Klimes-Dougan, Bonnie</creatorcontrib><creatorcontrib>Gabbay, Vilma</creatorcontrib><creatorcontrib>Hulvershorn, Leslie</creatorcontrib><creatorcontrib>Mueller, Bryon A.</creatorcontrib><creatorcontrib>Camchong, Jazmin</creatorcontrib><creatorcontrib>Bell, Christopher J.</creatorcontrib><creatorcontrib>Houri, Alaa</creatorcontrib><creatorcontrib>Kumra, Sanjiv</creatorcontrib><creatorcontrib>Lim, Kelvin O.</creatorcontrib><creatorcontrib>Castellanos, F. Xavier</creatorcontrib><creatorcontrib>Milham, Michael P.</creatorcontrib><title>A preliminary study of functional connectivity in comorbid adolescent depression</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the subgenual anterior cingulate cortex (ACC). Developmental changes in brain networks during adolescence highlight the need to examine MDD-related circuitry in teens separately from adults. Using resting state functional magnetic resonance imaging (fMRI), this study examined functional connectivity in adolescents with MDD (
n
=
12) and healthy adolescents (
n
=
14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Amygdala - blood supply</subject><subject>Amygdala - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain imaging</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Depression</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Echo-Planar Imaging</subject><subject>Female</subject><subject>Functional connectivity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gyrus Cinguli - blood supply</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Nerve Net - physiopathology</subject><subject>Resting state functional MRI</subject><subject>Subgenual anterior cingulate cortex</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuKFDEUDaI47egfiNRGd1XevDsbYRh8wYAudB1SqVuapippk6qG_nvTdDOjG12FS845nAchLyl0FKh6u-sirhMuHQMwHcgOGHtENnSrWauNZo_JBjiIlhsBV-RZKTsAkFSKp-SKGiGUArYhX2-afcYpzCG6fGzKsg7HJo3NuEa_hBTd1PgUI9bjEJZjE2K955T7MDRuSBMWj3FpBqwqpVTCc_JkdFPBF5f3mnz_8P7b7af27svHz7c3d62XjC0tUlTKjEYNZoCh90puFUqudS-d3HLJpAaUxulecAYSt5oDNU5wt2Wy145fk3dn3f3azzicXGQ32X0Ocw1ikwv2758Yftof6WCZplyBqgJvLgI5_VqxLHYONcw0uYhpLVZpwYwx8r_A2r-mivMKFGegz6mUjOO9Gwr2tJnd2fNmJ46xIG3drNJe_ZnkgXQZqQJeXwCueDeN2UUfyj2OUc04E_ShEqy9HwJmW3zA6HEIuQ5ohxT-7eQ3m-K4Vw</recordid><startdate>20090904</startdate><enddate>20090904</enddate><creator>Cullen, Kathryn R.</creator><creator>Gee, Dylan G.</creator><creator>Klimes-Dougan, Bonnie</creator><creator>Gabbay, Vilma</creator><creator>Hulvershorn, Leslie</creator><creator>Mueller, Bryon A.</creator><creator>Camchong, Jazmin</creator><creator>Bell, Christopher J.</creator><creator>Houri, Alaa</creator><creator>Kumra, Sanjiv</creator><creator>Lim, Kelvin O.</creator><creator>Castellanos, F. Xavier</creator><creator>Milham, Michael P.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090904</creationdate><title>A preliminary study of functional connectivity in comorbid adolescent depression</title><author>Cullen, Kathryn R. ; Gee, Dylan G. ; Klimes-Dougan, Bonnie ; Gabbay, Vilma ; Hulvershorn, Leslie ; Mueller, Bryon A. ; Camchong, Jazmin ; Bell, Christopher J. ; Houri, Alaa ; Kumra, Sanjiv ; Lim, Kelvin O. ; Castellanos, F. 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Psychology</topic><topic>Gyrus Cinguli - blood supply</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Nerve Net - physiopathology</topic><topic>Resting state functional MRI</topic><topic>Subgenual anterior cingulate cortex</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cullen, Kathryn R.</creatorcontrib><creatorcontrib>Gee, Dylan G.</creatorcontrib><creatorcontrib>Klimes-Dougan, Bonnie</creatorcontrib><creatorcontrib>Gabbay, Vilma</creatorcontrib><creatorcontrib>Hulvershorn, Leslie</creatorcontrib><creatorcontrib>Mueller, Bryon A.</creatorcontrib><creatorcontrib>Camchong, Jazmin</creatorcontrib><creatorcontrib>Bell, Christopher J.</creatorcontrib><creatorcontrib>Houri, Alaa</creatorcontrib><creatorcontrib>Kumra, Sanjiv</creatorcontrib><creatorcontrib>Lim, Kelvin O.</creatorcontrib><creatorcontrib>Castellanos, F. Xavier</creatorcontrib><creatorcontrib>Milham, Michael P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cullen, Kathryn R.</au><au>Gee, Dylan G.</au><au>Klimes-Dougan, Bonnie</au><au>Gabbay, Vilma</au><au>Hulvershorn, Leslie</au><au>Mueller, Bryon A.</au><au>Camchong, Jazmin</au><au>Bell, Christopher J.</au><au>Houri, Alaa</au><au>Kumra, Sanjiv</au><au>Lim, Kelvin O.</au><au>Castellanos, F. Xavier</au><au>Milham, Michael P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary study of functional connectivity in comorbid adolescent depression</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2009-09-04</date><risdate>2009</risdate><volume>460</volume><issue>3</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Major depressive disorder (MDD) begins frequently in adolescence and is associated with severe outcomes, but the developmental neurobiology of MDD is not well understood. Research in adults has implicated fronto-limbic neural networks in the pathophysiology of MDD, particularly in relation to the subgenual anterior cingulate cortex (ACC). Developmental changes in brain networks during adolescence highlight the need to examine MDD-related circuitry in teens separately from adults. Using resting state functional magnetic resonance imaging (fMRI), this study examined functional connectivity in adolescents with MDD (
n
=
12) and healthy adolescents (
n
=
14). Seed-based connectivity analysis revealed that adolescents with MDD have decreased functional connectivity in a subgenual ACC-based neural network that includes the supragenual ACC (BA 32), the right medial frontal cortex (BA 10), the left inferior (BA 47) and superior frontal cortex (BA 22), superior temporal gyrus (BA 22), and the insular cortex (BA 13). These preliminary data suggest that MDD in adolescence is associated with abnormal connectivity within neural circuits that mediate emotion processing. Future research in larger, un-medicated samples will be necessary to confirm this finding. We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19446602</pmid><doi>10.1016/j.neulet.2009.05.022</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescence Adolescent Amygdala - blood supply Amygdala - physiopathology Biological and medical sciences Brain imaging Brain Mapping Cerebral Cortex - blood supply Cerebral Cortex - physiopathology Depression Depressive Disorder, Major - physiopathology Echo-Planar Imaging Female Functional connectivity Fundamental and applied biological sciences. Psychology Gyrus Cinguli - blood supply Gyrus Cinguli - physiopathology Humans Male Nerve Net - physiopathology Resting state functional MRI Subgenual anterior cingulate cortex Vertebrates: nervous system and sense organs Young Adult |
| title | A preliminary study of functional connectivity in comorbid adolescent depression |
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