MicroRNA-155 Modulates the Pathogen Binding Ability of Dendritic Cells (DCs) by Down-regulation of DC-specific Intercellular Adhesion Molecule-3 Grabbing Non-integrin (DC-SIGN)

MicroRNA-155 (miR-155) has been involved in the response to inflammation in macrophages and lymphocytes. Here we show how miR-155 participates in the maturation of human dendritic cells (DC) and modulates pathogen binding by down-regulating DC-specific intercellular adhesion molecule-3 grabbing non-...

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Veröffentlicht in:	The Journal of biological chemistry 2009-06, Vol.284 (24), p.16334-16342
Hauptverfasser:	Martinez-Nunez, Rocio T., Louafi, Fethi, Friedmann, Peter S., Sanchez-Elsner, Tilman
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Candida albicans - immunology Candidiasis - immunology Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Dendritic Cells - cytology Dendritic Cells - physiology Down-Regulation - immunology Gene Expression Regulation - immunology HeLa Cells HIV Envelope Protein gp120 - immunology HIV Envelope Protein gp120 - metabolism HIV Infections - immunology Human immunodeficiency virus Humans Lectins, C-Type - genetics Lectins, C-Type - metabolism MicroRNAs - immunology MicroRNAs - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA-Mediated Regulation and Noncoding RNAs T-Lymphocytes - cytology Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation - immunology
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