Cholesterol Modulates the Interaction of β-Amyloid Peptide with Lipid Bilayers

The interaction of an amphiphilic, 40-amino acid β-amyloid (Aβ) peptide with liposomal membranes as a function of sterol mole fraction (Xsterol) was studied based on the fluorescence anisotropy of a site-specific membrane sterol probe, dehydroergosterol (DHE), and fluorescence resonance energy trans...

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Veröffentlicht in:	Biophysical journal 2009-05, Vol.96 (10), p.4299-4307
Hauptverfasser:	Qiu, Liming, Lewis, Anthony, Como, John, Vaughn, Mark W., Huang, Juyang, Somerharju, Pentti, Virtanen, Jorma, Cheng, Kwan Hon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Amino Acid Sequence Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Cell Biophysics Cholesterol - metabolism Ergosterol - analogs & derivatives Ergosterol - metabolism Fluorescence Polarization Fluorescence Resonance Energy Transfer Lipid Bilayers - chemistry Lipid Bilayers - metabolism Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Binding Time Factors Tyrosine - metabolism
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