β8 Integrin Binds Rho GDP Dissociation Inhibitor-1 and Activates Rac1 to Inhibit Mesangial Cell Myofibroblast Differentiation

αvβ8 integrin expression is restricted primarily to kidney, brain, and placenta. Targeted αvor β8 deletion is embryonic lethal due to defective placenta and brain angiogenesis, precluding investigation of kidney αvβ8 function. We find that kidney β8 is localized to glomerular mesangial cells, and ex...

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Veröffentlicht in:	The Journal of biological chemistry 2006-07, Vol.281 (28), p.19688-19699
Hauptverfasser:	Lakhe-Reddy, Sujata, Khan, Shenaz, Konieczkowski, Martha, Jarad, George, Wu, Karen L., Reichardt, Louis F., Takai, Yoshimi, Bruggeman, Leslie A., Wang, Bingcheng, Sedor, John R., Schelling, Jeffrey R.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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